Indexing
All Issues
Submission
Author Guidelines
Reviewers
Editorial Members
Publication Fee
Vol.3 , No. 4, Publication Date: Aug. 27, 2016, Page: 64-71
. The combination was individually adjusted and consisted of: deproteinated calf serum, dimethylsulfoxide, oxytocin, glutathion, dopamine, vitamins B (group) and C; it had positive and notable effects both in neurologically normal and in patients with neurological pathology (post-stroke).&picture=http://www.aascit.org/aascit/decorators/img/journal/906.jpg)
| [1] | Felician Stancioiu, The Bio-Forum Foundation, Bucharest, Romania. |
| [2] | Daniela Catanas, The Bio-Forum Foundation, Bucharest, Romania. |
A new combination of substances, already in use individually for treating various human pathologies, was administered intravenously to 11 neurologically normal patients and 3 patients with stroke or transient ischemic attack which occurred at least 1 week prior to treatment. A total of 22 such infusions were given beginning with October 2014 with good results and minor side effects (restless first night after infusion). The combination was individually adjusted and consisted of: deproteinated calf serum, dimethylsulfoxide, oxytocin, glutathion, dopamine, vitamins B (group) and C; it had positive and notable effects both in neurologically normal and in patients with neurological pathology (post-stroke).
Keywords
Stroke, Post-Stroke, Regenerative, Neuropsychological, Chronic Stroke Treatment, Regenerative Medicine
Reference
| [01] | Gould E, Reeves AJ, Graziano MSA, Gross CG. Neurogenesis in the Neocortex of Adult Primates Science 15 Oct 1999: Vol. 286, Issue 5439, pp. 548-552. DOI: 10.1126/science.286.5439.548 |
| [02] | Louveau A, et al., Structural and functional features of central nervous system lymphatic vessels. Nature 523, 337–341 (16 July 2015) doi: 10.1038/nature14432 |
| [03] | Filiano Anthony J et al, Unexpected role of interferon-γ in regulating neuronal connectivity and social behaviour, Nature 535, 425–429 (21 July 2016). DOI: 10.1038/nature18626 |
| [04] | A Study of Allogeneic Mesenchymal Bone Marrow Cells in Subjects With Ischemic Stroke. https://clinicaltrials.gov/ct2/show/NCT01297413; accessed July 2016 |
| [05] | Human Umbilical Cord Mesenchymal Stem Cell in Cerebral Hemorrhage Sequela. (July 2016) https://clinicaltrials.gov/ct2/show/study/NCT02283879?term=brain+stem+cells&rank=12 |
| [06] | Efficacy Study of CD34 Stem Cell in Chronic Stroke Patients. (July 2016) https://clinicaltrials.gov/ct2/show/NCT00950521?term=brain+stem+cells&rank=39 |
| [07] | Imitola J, et al. Directed migration of neural stem cells to sites of CNS injury by the stromal cell- derived factor 1α/CXC chemokine receptor 4 pathway. PNAS December 28, 2004 vol. 101 no. 52, 18117–18122 |
| [08] | Yurinskaya MM, Astashkin E, Grachev SV, Vinokurov MG. Actovegin protects human neuroblastoma cells SK-N-SH from apoptosis induced by hydrogen peroxide through the PI3K and p38 MAPK signaling pathways. Biochemistry (Moscow) Supplement Series A Membrane and Cell Biology 10 (1): 68-72 •January 2016 DOI: 10.1134/S1990747815050207 |
| [09] | Machicao F, Muresanu D, Hundsberger H, Guekht A. Pleiotropic neuroprotective and metabolic effects of Actovegin's mode of action. Journal of the neurological sciences 322 (1-2): 222-7 August 2012 DOI: 10.1016/j.jns.2012.07.069 |
| [10] | Gulevsky, A K, Abakumova, Y S, Nikolaevna Moiseyeva N, Ivanov Y G. "Influence of Cord Blood Fraction (below 5 kDa) on Reparative Processes During Subchronic Ulcerative Gastropathy." Ulcers. 2011, p. 1-9. Hindawi Publishing Corporation Ulcers Volume 2011, doi: 10.1155/2011/214124 |
| [11] | Kuninaka T, Senga Y, Senga H, Weiner M: Nature of enhanced mitochondrial oxidative metabolism by a calf blood extract. J Cell Physiol 1991; 146: 148–155 |
| [12] | De Groot, Brecht M, Machicao F: Evidence for a factor protective against hypoxic liver parenchymal cell injury in a protein-free blood extract. Res Comm Chem Path Pharm 1990; 68: 125–128 |
| [13] | Jacob S, Dietze GJ, Machicao F, Kuntz G, Augustin HJ: Improvement of glucose metabolism in patients with type II diabetes after treatment with a hemodialysate. Arzneimittelforschung 1996; 46: 269–272 |
| [14] | Petrov VI, Ponomarev EA, Maskin SS, Strepetov NN. Pharmacological neuroprotection against brain damage in ischemia/reperfusion experiment. Eksperimental'naia i klinicheskaia farmakologiia 74 (8): 13-6January 2011 |
| [15] | Bing Zhou, Panpan Yu, Mei-Yao Lin, Tao Sun, Yanmin Chen, Zu-Hang Sheng. Facilitation of axon regeneration by enhancing mitochondrial transport and rescuing energy deficits. Journal Cell Biology vol. 214 no. 1 103-119. Published June 7, 2016. doi: 10.1083/jcb.201605101 |
| [16] | Demchenko E. Yu., Kulakova NV, Semfglazova TA, Udut VV. Metabolic effects of mexidol in complex treatment of chronic brain ischemia. Eksperimental'naia i klinicheskaia farmakologiia 71 (6): 13-15 November 2008 |
| [17] | Beibei Dong, Min Cai, Zongping Fang, Haidong Wei, Fangyun Zhu, Guochao Li, Hailong Dong, Lize Xiong. Hemopexin induces neuroprotection in the rat subjected to focal cerebral ischemia. BMC Neuroscience 2013, 14: 58. http://www.biomedcentral.com/1471-2202/14/58 |
| [18] | Yin CG, Jiang L, Tang B, Zhang H, Qian Q, Niu GZ. Prognostic significance of plasma visfatin levels in patients with ischemic stroke. Peptides. 2013 Apr; 42: 101-4. doi: 10.1016/j.peptides. 2013.01.005. Epub 2013 Jan 15 |
| [19] | Kamińska A, Borkowska A, Kopczyńska E, Tyrakowski T, Bronisz A, Roman Junik R, Żmudzińska M. An evaluation of visfatin levels in obese subjects. Endokrynologia Polska/Polish Journal of Endocrinology. Volume 61; Number 2/2010. ISSN 0423–104X |
| [20] | Semlitsch H V, Anderer P, Saletu B, Hochmayer I. Topographic Mapping of Cognitive Event- Related Potentials in a Double-Blind, Placebo-Controlled Study with the Hemoderivative Actovegin in Age-Associated Memory Impairment. Neuropsychobiology 24 (1): 49-56 January 1991. DOI: 10.1159/000119042 |
| [21] | Saletu B., Grunberger J, Linzmayer L, Semlitsch H V. EEG Brain Mapping and Psychometry in Age- Associated Memory Impairment after Acute and 2-Week Infusions with the Hemoderivative Actovegin®: Double-Blind, Placebo-Controlled Trials. Neuropsychobiology 24 (3): 135-48 • January 1991. DOI: 10.1159/000119476 |
| [22] | Beristain Xabier, Golombievski E. Pharmacotherapy to Enhance Cognitive and Motor Recovery Following Stroke. Drugs Aging. Online 30 September 2015. DOI 10.1007/s40266-015-0299-0 |
| [23] | Derev'yannykh EA, Bel'skaya GN, Knoll EA, Krylova LG, Popov DV (October 2008). "Experience in the use of Actovegin in the treatment of patients with cognitive disorders in the acute period of stroke". Neurosci. Behav. Physiol. 38 (8): 873–5. doi: 10.1007/s11055-008-9051- |
| [24] | Kanowski S, Kinzler E, Lehman E, Kuntz G. Confirmed Clinical Efficacy of Actovegin ® in Elderly Patients with Organic Brain Syndrome. Pharmacopsychiatry 28 (4): 125-33 July 1995 DOI: 10.1055/s-2007-979604 |
| [25] | Efficacy and Safety of Actovegin in Post-stroke Cognitive Impairment (PSCI) (ARTEMIDA https://clinicaltrials.gov/ct2/show/results/NCT01582854?sect=X301256#evnt Accessed July 2016 |
| [26] | Elisia I, Nakamura H, Lam V, Hofs E, Cederberg R, Cait J, Hughes MR, Lee L, Jia W, Adomat HH, Guns ES, McNagny KM, Samudio I, Krystal G. DMSO Represses Inflammatory Cytokine Production from Human Blood Cells and Reduces Autoimmune Arthritis. PLoS One. 2016 Mar 31; 11 (3): e0152538. doi: 10.1371/journal.pone.0152538 |
| [27] | Wattananit S et al. Monocyte-Derived Macrophages Contribute to Spontaneous Long-Term Functional Recovery after Stroke in Mice, Journal of Neuroscience (2016). DOI: 10.1523/ JNEUROSCI.4317-15.2016 |
| [28] | Hamala¨inen et al. mtDNA Mutagenesis Disrupts Pluripotent Stem Cell Function by Altering Redox Signaling, Cell Reports. Volume 11, Issue 10, p1614–1624, 16 June 2015 DOI: http://dx.doi.org/10.1016/j.celrep.2015.05.009 |
| [29] | Jing Y, Zhang JC, Li ST, Zhao JH, Wang J, Han XF, Xing Y. Wnt/β-catenin pathway might underlie the MET in trans- differentiation from MSC to MSC-derived neuron. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2015 Nov; 31 (6): 572-6 |
| [30] | Eckstein M, Scheele D, Patin A, et. al., Oxytocin Facilitates Pavlovian Fear Learning in Males. Neuropsychopharmacology. 2016 Mar; 41 (4): 932-9. doi: 10.1038/npp.2015.245 |
| [31] | Eckstein M, Becker B, Scheele D, Scholz C, et al. Oxytocin facilitates the extinction of conditioned fear in humans. Biol Psychiatry. 2015 Aug 1; 78 (3): 194-202. doi: 10.1016/j.biopsych.2014.10.015 |
| [32] | Zhang X, van den Pol AN. Dopamine/Tyrosine Hydroxylase Neurons of the Hypothalamic Arcuate Nucleus Release GABA, Communicate with Dopaminergic and Other Arcuate Neurons, and Respond to Dynorphin, Met-Enkephalin, and Oxytocin. J Neurosci. 2015 Nov 11; 35 (45): 14966-82. doi: 10.1523/JNEUROSCI.0293-15.2015. |
| [33] | De Dreu CK, Baas M, Roskes M, Sligte DJ, Ebstein RP, et al. Oxytonergic circuitry sustains and enables creative cognition in humans. Soc Cogn Affect Neurosci. 2014 Aug; 9 (8): 1159-65. doi: 10.1093/scan/nst094 |
| [34] | De Dreu CK, Baas M, Boot NC. Oxytocin enables novelty seeking and creative performance through upregulated approach: evidence and avenues for future research. Wiley Interdiscip Rev Cogn Sci. 2015 Sep-Oct; 6 (5): 409-17. doi: 10.1002/wcs.1354 |
| [35] | Sánchez-Vidaña DI, Chan NJ, Chan AH, Hui KK, et al. Repeated treatment with oxytocin promotes hippocampal cell proliferation, dendritic maturation and affects socio-emotional behavior. Neuroscience. 2016 Jul 11; 333: 65-77. doi: 10.1016/j.neuroscience.2016.07.005 |
| [36] | Melis MR, Succu S, Sanna F, Boi A, Argiolas A. Oxytocin injected into the ventral subiculum or the posteromedial cortical nucleus of the amygdala induces penile erection and increases extracellular dopamine levels in the nucleus accumbens of male rats. Eur J Neurosci. 2009 Oct; 30 (7): 1349-57. doi: 10.1111/j.1460-9568.2009.06912 |
| [37] | Jafarzadeh N, Javeri A, Khaleghi M, Taha MF. Oxytocin improves proliferation and neural differentiation of adipose tissue-derived stem cells. Neurosci Lett. 2014 Apr 3; 564: 105-10. doi: 10.1016/j.neulet.2014.02.012 |
| [38] | Angioni L, Cocco C, Ferri GL, Argiolas A, Melis MR, Sanna F. Involvement of nigral oxytocin in locomotor activity: A behavioral, immunohistochemical and lesion study in male rats. Horm Behav. 2016 Jul; 83: 23-38. doi: 10.1016/j.yhbeh.2016.05.012. Epub 2016 May 14 |
| [39] | Leuner B1, Caponiti JM, Gould E. Oxytocin stimulates adult neurogenesis even under conditions of stress and elevated glucocorticoids. Hippocampus. 2012 Apr; 22 (4): 861-8. doi: 10.1002/hipo.20947. Epub 2011 Jun 20 |
| [40] | Campbell CVB, Mitchell JP, Kleinig TJ, Dewey HM, Churilov L, Yassi N, Yan B, et al for the EXTEND-IA Investigators. Endovascular Therapy for Ischemic Stroke with Perfusion-Imaging Selection. N Engl J Med 2015; 372: 1009-1018. March 12, 2015 DOI: 10.1056/NEJMoa1414792 |
