Indexing
All Issues
Submission
Author Guidelines
Reviewers
Editorial Members
Publication Fee
Vol.2 , No. 3, Publication Date: Sep. 8, 2017, Page: 12-15
| [1] | Ukwubile Cletus Anes, Department of Science Laboratory Technology, Biology Unit, School of Science and Technology, Federal Polytechnic, Bali, Nigeria. |
| [2] | Nettey Henry, Department of Pharmaceutics and Microbiology, University of Ghana School of Pharmacy, University of Ghana, Legon Accra, Ghana. |
Exosomes are nanoparticles that play a crucial role in intercellular communication. This research investigated the role of exosome as drug carrier in ovarian cancer therapy. Exosomes were isolated by ultracentrifugation of blood from the liver. Morphology of exosome-plant complex was studied using scanning electron and atomic force microscopes. Under optimal conditions for cancer therapy, exosome-loaded plant extract showed higher anti-ovarian cancer efficacy such as reduced viable cell, high inhibitory concentration, induced apoptosis, and prevention of metastasis of cancer cells than doxorubicin anticancer drug. Our results showed that exosome-loaded anti-ovarian cancer plant extract is a promising nanosized drug formulation for ovarian cancer therapy.
Keywords
Exosome, Nanoparticles, Anti-Ovarian Cancer, Plant Extract
Reference
| [01] | Li, E, Zeringer, T., Barta, J., Schageman, A., Cheng, and Vlassov, A. V. (2016). Analysis of the RNA content of the exosomes derived from blood serum and urine and its potential as bio-maker. Philosophical transactions of the Royal Society Biological Science: 3-33. |
| [02] | Basu, J., B Ludlow, J. W. (2016). Exosomes for repair, Regeneration and Rejuvenation Expert opinion on Biologic therapy; 3: 34-40. |
| [03] | Leiserowitz, G. S., Lebrilla, C., Miyamoto, S., An, H. J., Duong, H., Kirmiz, C., et al. (2008). Glycomics analysis of serum: a potential new biomarker for ovarian cancer? International Journal of Gynecologic Cancer; 18: 470-475. |
| [04] | Park, J. E., Tan, H. S., Datta, A., Lai, R. C., Zhang, H., Meng, W., Lim, S. K., Size, S. K. (2010). Hypoxic Tumor cell Modulates its micro environment to enhance Angiogenic and metastatic potentials by secretion of proteins and exosomes. Molecular and cellular proteomics; 9 (6): 56-67. |
| [05] | Qin, J., Q. xu. Function and application of exosomes. Acta Pol Phar. 2014: 71. |
| [06] | Shabbir, A., Cox, A., Rodriguez-menocal L., Salgodom. And Badiavas E. V. (2015). Mesenchymal stem cell exosomes induce proliferation and migration of normal and chronic wound fibroblast and enhance development; 24 (14): 1635-1647. |
| [07] | Alvarez-Erviti, L., Seow, Y., Yin, H., Betts, C., Lakhal, S., and Wood, M. S. (2011). Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes. Nat. Biotechnology; 29 (4): 341-5. |
| [08] | Vanderpole, E., Boing, A. N., Harrison P., Sturk A., and Nieuwland, R. (2012). Classification, function and clinical relevance of extracellular, vesicles. Journal of Pharmacology; 64 (3): 676-705. |
| [09] | Yeo, R., Lim, W. Y., and Lim, S. K. (2010). Exosomes and their therapeutic application inadvances in pharmaceutical cell therapy: principle of cell-based; Biopharmceutic; 3 (5): 477-501. |
| [10] | Kahlert, C., Kalluri, R. (2012). Exosomes in tumor microenvironment influence cancer progression and metastasis. Journal of Molecular Medicine (Berl); 91: 431-437. |
| [11] | Batrakova, E. V., Kim, M. S. (2015). Using exosomes, naturally-equipped nano-carriers for drug delivery. Journal of controlled release; 219: 396-405. |
