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Vol.2 , No. 2, Publication Date: Feb. 12, 2018, Page: 7-14
| [1] | Alejandro Soto Ospina, Faculty of Medicine, University of Antioquia, Medellín, Colombia. |
| [2] | Pedronel Araque Marín, Basic Sciences Department, University EIA (University School of Antioquia Engineering), Envigado, Colombia. |
American trypanosomiasis, commonly known as Chagas disease, is a desease with the highest prevalence in the tropics and is caused by the parasite Trypanosoma cruzi, whose vector is an insect from the Rhodnius prolixus family. The pathology of this disease is characterized by the presence of cardiopathies and gastrointestinal problems in patients during chronic phases. It should be noted that an approach of a structure of the orthosteric site that allows to explain the functionality and the plausible mechanism of reaction is important in order to understand the design of molecular targets or possible resistance generated in chronic phases of the disease. This is why the structural biology has tools such as the homology modelling and the structural assembly by sequence-based fold recognition to construct a model. Besides, the proposed models obtained by comparison with the reported structures are validated through energetic and stereochemical softwares that produce quantitative data, which characterize the structural models. The previous validation would allow to compare two predictive and structural refinement methods to generate the best methodology of elucidation.
Keywords
Structure, Trypanosoma-cruzi, Enzyme, Chagas Disease
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