AASCIT - Journal -Reviewers

Individual Information

Madhusudanarao Vuda

Department of Critical Care Medicine, McGill University Health center

Educational Qualification
From 10/2009 to 09/2012, PhD in Biomedical Sciences , Switzerland
From 09/2008 to 09/2009, MSc in Biomedicine , Sweden
From 09/2004 to 02/2008, MSc Medical Pharmacology , India
Research Interests
Aging
Sepsis
Mitochondrial function in health and disease
skeletal muscle denervation
drug toxicity
bioenergetics
Oxidative stress
muscle atrophy
Work Experience
From 01/2012 to 11/2016, Postdoctoral fellow , McGill University, Canada
From 09/2009 to 08/2012, Research fellow , Bern University hospital , Switzerland
From 03/2008 to 07/2008, Lecturer in Pharmacology , AJ Institute of Medical sciences, India
Selected Publications

Journal Articles

1.	Vuda M, Kamath A. Drug induced mitochondrial dysfunction: Mechanisms and adverse clinical consequences. Mitochondrion. 2016 Oct 19. pii: S1567-7249(16)30211-2. [Epub ahead of print] Review.
2.	Spendiff S, Vuda M, Gouspillou G, Aare S, Perez A, Morais J, Jagoe RT, Filion ME, Glicksman R, Kapchinsky S, MacMillan M, Pion CH, Leheudre MA, Hettwer S, Correa JA, Taivassalo T, and Hepple RT. Denervation Drives Mitochondrial Dysfunction in Skeletal Muscle of Octogenarians. J Physiol. 2016 Sep 13. doi: 10.1113/JP272487. [Epub ahead of print]. *Contributed equally
3.	Aare S, Spendiff S, Vuda M, Perez A, Wu Q, Mayaki D, Hettwer S, Hussain S, and Hepple RT. Failed Reinnervation in Aging Skeletal Muscle. Skelet Muscle. 2016 Sep 1;6(1):29.
4.	Djafarzadeh S, Vuda M, Jeger V, Takala J, Jakob SM. Effect of fentanil on hepatic mitochondrial function. Anesth Analg. 2016;123(2):311-25.
5.	Gouspillou G, Scheede-Bergdahl C, Spendiff S, Vuda M, Meehan B, Mlynarski H, Archer-Lahlou E, Sgarioto N, Purves-Smith FM, Konokhova Y, Rak J, Chevalier S, Taivassalo T, Hepple RT, Jagoe RT. Anthracycline-containing chemotherapy causes long-term impairment of mitochondrial respiration and increased reactive oxygen species release in skeletal muscle. Sci Rep. 2015; 3;5: 8717.
6.	Corrêa TD, Vuda M, Takala J, Djafarzadeh S, Silva E, Jakob SM. Increasing mean arterial blood pressure in sepsis: effects on fluid balance, vasopressor load and renal function. Crit Care. 2013;17(1):R21. *Contributed equally
7.	Djafarzadeh S, Vuda M, Takala J, Jakob SM. Effect of remifentanil on mitochondrial oxygen consumption of cultured human hepatocytes. PLoS One. 2012;7(9):e45195
8.	Corrêa TD, Vuda M, Blaser AR, Takala J, Djafarzadeh S, Dünser MW, Silva E, Lensch M, Wilkens L, Jakob SM. Effect of treatment delay on disease severity and need for resuscitation in porcine fecal peritonitis. Crit Care Med. 2012;40(10):2841-9. *Contributed equally
9.	Vuda M, Brander L, Schr?der R, Jakob SM, Takala J, Djafarzadeh S. Effects of catecholamines on hepatic and skeletal muscle mitochondrial respiration after prolonged exposure to faecal peritonitis in pigs. Innate Immun. 2012;18(2):217-30
10.	Vuda M, D'Souza R, Upadhya S, Kumar V, Rao N, Kumar V, Boillat C, Mungli P. Hepatoprotective and antioxidant activity of aqueous extract of Hybanthus enneaspermus against CCl4-induced liver injury in rats. Exp Toxicol Pathol. 2012;64(7-8):855-9
11.	Djafarzadeh S, Vuda M, Takala J, Ochs M, Jakob SM. Toll-like receptor-3-induced mitochondrial dysfunction in cultured human hepatocytes. Mitochondrion. 2011;11(1):83-8.
12.	Regueira T, Lepper PM, Brandt S, Ochs M, Vuda M, Takala J, Jakob SM, Djafarzadeh S. Hypoxia inducible factor-1 alpha induction by tumour necrosis factor-alpha, but not by toll-like receptor agonists, modulates cellular respiration in cultured human hepatocytes. Liver Int. 2009;29(10):1582-92

Conference Papers

1.	Aare S, Gove T, Vuda M and Hepple RT. Transcriptional evidence for failed reinnervation in aging muscle. The FASEB Journal, 2015, vol. 29 no. 1 Supplement LB220.
2.	Spendiff S, Vuda M, Giouspillou G, Aare S, Filion ME, Kapchinsky S, Morais J, Jagoe RT, Taivassalo T, Hettwer S, Hepple RT. Primary versus Secondary Mitochondrial Function Alterations in Aging Muscle. The FASEB Journal 2015: vol. 29 no. 1 Supplement 815.4
3.	Vuda M, Aare S, Perez A. Spendiff S, Taivassalo T, Hettwer S, Hepple R. Impact of sporadic denervation on muscle mitochondrial function in neurotrypsin over-expressing mice and its implications for aging muscle. Journal of Muscle Research and Cell Motility 2015: Vol 36, Issue 1, pp 71-143.
4.	Spendiff S, Filion ME, Giouspillou G, Wright K, Vuda M, Morais J, Hepple RT, Taivassalo T. No protection of muscle mitochondrial function in elite octogenarian master athletes". J Frailty Aging 2014;3(1):25-83.
5.	Jeger V, Vuda M, Correa T, Takala J, Djafarzadeh S, Jakob SM. Norepinephrine vs. Angiotensin II in septic shock: effects on isolated kidney, heart and liver mitochondrial respiration. Critical Care 2012, 16(Suppl 1):P196.
6.	Correa T.D, Jeger V, Vuda M, Djafarzadeh S, Takala J, Jakob S.M. Norepinephrine versus Angiotensin-II as vasopressors in septic shock: Effects on inflammatory response, tissue perfusion and organ function in a porcine model of fecal peritonitis. Intensive Care Med. 2012;38 Suppl 1:S8-327.
7.	Vuda M, Chiusa M, Jakob SM, Takala J, Zuppinger C, Djafarzadeh S. Lipopolysaccharide (LPS) induces mitochondrial dysfunction in rat cardiac microvascular endothelial cells. Critical Care 2011, 15(Suppl 1):P245.
8.	Hostettler S, Vuda M, Correa TD, Djafarzadeh S, Takala J, Jakob SM. Systemic oxygen consumption and mitochondrial respiration are maintained in lethal fecal peritonitis. Intensive Care Medicine, 2011, 37, (Suppl 2): S118:P0450.
9.	Correa TD, Vuda M, Djafarzadeh S, Takala J, Lensch M, Jakob SM. Increasing mean arterial blood pressure in sepsis: Effects on renal function, fluid balance and vasopressor load. Intensive Care Medicine, 2011, 37, (Suppl 2): S259: P1013
10.	Vuda M, Correa TD, Reintam A, Takala J, Jakob SM, Djafarzadeh S. Time to resuscitation: effects on mitochondrial function and outcome in experimental sepsis model. Intensive Care Medicine, 2010, 36 (Suppl 2): S409: P1289.