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Vol.4 , No. 2, Publication Date: May 16, 2018, Page: 25-31
. The sedated animal was weighed on a weighing balance and figure recorded. The animal was then perfused to clear blood from the organs before the organs were harvested. The kidneys were removed, weighed and fixed by immersion in 4% formal saline for further histological processing. The result showed the total body weight appeared to be significantly (p<0.05) lower in groups B, C and D when compared to the control group (29.00±2.31g) and is significantly (p < 0.05) higher in groups B and C when compared to the control. Also, total body length, right and left kidneys showed a significant (p<0.05) increased in group B when compared to the control group in both male and female. Abnormalities in the functional components of the kidney were observed with a rise in the administered dose, with the condition being most severe in the group treated with 70mg administration. It is concluded that high levels of lactational lead is very toxic to rat pups causing histoarchitectural pathologies in the kidney.&picture=http://www.aascit.org/aascit/decorators/img/journal/979.jpg)
| [1] | Odukoya Samson Ayodeji, Department of Anatomy and Cell Biology, Faculty of Basic Medical Sciences, Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria. |
| [2] | Olatunji Olanrewaju James, Department of Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, Bowen University, Iwo Osun State, Nigeria. |
| [3] | Komolafe Omobola Aderibigbe, Department of Anatomy and Cell Biology, Faculty of Basic Medical Sciences, Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria. |
| [4] | Saka Olusola Stephen, Department of Anatomy and Cell Biology, Faculty of Basic Medical Sciences, Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria. |
| [5] | Odukoya Abimbola Opeyemi, Obafemi Awolowo Teaching Hospital Complex, Ile Ife, Osun-State, Nigeria. |
This study was designed to examine the effect oflactational lead intoxication in the kidney of Sprague-Dawley rats. 12 female rats were used in the experiment. These rats mated with male rats to reproduce 23 offspring for the analysis of lactational lead intoxication. The offspring were divided into four groups. Groups B, C and D were administered 10 mg/dL, 30 mg/dL and 70 mg/dL of lead acetate respectively while group A was control. The animal was firstly sedated using a chloroform-damped cotton wool in a vacuum (air-tight chamber). The sedated animal was weighed on a weighing balance and figure recorded. The animal was then perfused to clear blood from the organs before the organs were harvested. The kidneys were removed, weighed and fixed by immersion in 4% formal saline for further histological processing. The result showed the total body weight appeared to be significantly (p<0.05) lower in groups B, C and D when compared to the control group (29.00±2.31g) and is significantly (p < 0.05) higher in groups B and C when compared to the control. Also, total body length, right and left kidneys showed a significant (p<0.05) increased in group B when compared to the control group in both male and female. Abnormalities in the functional components of the kidney were observed with a rise in the administered dose, with the condition being most severe in the group treated with 70mg administration. It is concluded that high levels of lactational lead is very toxic to rat pups causing histoarchitectural pathologies in the kidney.
Keywords
Lactational, Lead, Intoxication, Kidney
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