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Vol.4 , No. 1, Publication Date: Jan. 11, 2018, Page: 5-8
, vitamin E and selenium (natural antioxidants) in serum samples of patients with calcium containing kidney stones and in control subjects in order to observe their role in the pathogenesis of calcium containing kidney stones. For this purpose 80 subjects including 40 confirmed cases of calcium containing kidney stones and 40 age and gender matched control subjects with no personal or family history of urolithiasis were recruited from the OPD of Liaquat University Hospital Jamshoro and Isra University Hospital Hyderabad during June 2012 to December 2012. Serum malondialdehyde (MDA), vitamin E and selenium levels were measured by spectrophotometric methods using commercially available kits. Serum MDA levels were found to be significantly higher (p<0.001) and of vitamin E and selenium significantly (p<0.001) lower in calcium containing kidney stone patients as against the control subjects. A weak positive correlation (which was not statistically significant) was seen between serum MDA and vitamin E levels and between MDA and selenium levels. The results of present study suggest that lipid peroxidation owning to decreased amounts of antioxidants seems to play a major role in the pathogenesis of calcium containing kidney stones.&picture=http://www.aascit.org/aascit/decorators/img/journal/971.jpg)
| [1] | Fatehuddin Khand, Department of Biochemistry, Isra University, Hyderabad, Pakistan. |
| [2] | Maria Kazi, Department of Biochemistry, Isra University, Hyderabad, Pakistan. |
| [3] | Ikram Udin Ujjan, Department of Pathology, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan. |
The aim of present study was to assess the levels of malondialdehyde (marker of lipid peroxidation), vitamin E and selenium (natural antioxidants) in serum samples of patients with calcium containing kidney stones and in control subjects in order to observe their role in the pathogenesis of calcium containing kidney stones. For this purpose 80 subjects including 40 confirmed cases of calcium containing kidney stones and 40 age and gender matched control subjects with no personal or family history of urolithiasis were recruited from the OPD of Liaquat University Hospital Jamshoro and Isra University Hospital Hyderabad during June 2012 to December 2012. Serum malondialdehyde (MDA), vitamin E and selenium levels were measured by spectrophotometric methods using commercially available kits. Serum MDA levels were found to be significantly higher (p<0.001) and of vitamin E and selenium significantly (p<0.001) lower in calcium containing kidney stone patients as against the control subjects. A weak positive correlation (which was not statistically significant) was seen between serum MDA and vitamin E levels and between MDA and selenium levels. The results of present study suggest that lipid peroxidation owning to decreased amounts of antioxidants seems to play a major role in the pathogenesis of calcium containing kidney stones.
Keywords
Malondialdehyde, Vitamin E, Selenium, Calcium Containing Kidney Stones
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