ISSN Print: 2381-1250  ISSN Online: 2381-1269
AASCIT Journal of Bioscience  
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Amelioration of Some Indices of Diabetic Complications Using Senna occidentalis Leaf Extract in Alloxan-Induced Diabetes in Rats
AASCIT Journal of Bioscience
Vol.3 , No. 4, Publication Date: Aug. 30, 2017, Page: 24-28
531 Views Since August 30, 2017, 167 Downloads Since Aug. 30, 2017

Ojochenemi Ejeh Yakubu, Department of Biochemistry, Faculty of Pure and Apllied Sciences, Federal University Wukari, Wukari, Nigeria.


This study was designed to investigate the ameliorative effects of some indices of diabetic complications using Senna occidentalis leaf extract in alloxan-induced diabetes in rats. Thirty male Wistar rats with body weight ranging from 150–200 g were selected for the study. Diabetes was induced by single intraperitoneal dose of alloxan injection (150 mg/ kg body weight). Rats were treated orally using aqueous and ethanol extracts of Senna occidentalis leaves at 100 mg/kg body weight once daily for 21-days. The fasting blood sugar (FBS), Thiobarbituric acid Reactive Substance (TBARS), alkaline Phosphatase (ALP), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were analysed spectrophotometrically. The result of the study showed that treatment of diabetic rats with the extract caused significant (p<0.05) decrease in FBS, TBARS, ALP, ALT and AST. The result of study showed to a large extent the effects of Senna occidentalis in the amelioration of some complications resulting from diabetes.


Senna occidentalis, Biochemical Complications, Diabetes


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