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American Journal of Pharmacy and Pharmacology

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Anti-Proliferative Allylic Phenols from the Methanol Extract of Piper betle

American Journal of Pharmacy and Pharmacology
Vol.5 , No. 3, Publication Date: May 31, 2018, Page: 13-18

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Authors

[1]	Ajoy Kumar Bauri, Bio-Organic Division, Bhabha Atomic Research Centre, Mumbai, India.
[2]	Peggy Jane Brodie, Department of Chemistry, Virginia Tech, Blacksburg, USA.
[3]	David George Ican Kingston, Department of Chemistry, Virginia Tech, Blacksburg, USA.

Abstract

Fractionation of a defatted methanol extract of Piper betle Linn led to the isolation of two cytotoxic allyl phenolic compounds (3 and 4) together with 1. The structures of the compounds have been confirmed in comparison with reported data available in literature. Allyl phenol 2 and semi-synthetic compounds (4-6) were prepared in order to evaluate their activity against A2780 cell lines and to establish the structure activity relationship of these compounds.

Keywords

Piper betle Leaf, Allyl Phenols, Anti-proliferative Activity, Structure-Activity Relationship

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