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Vol.1 , No. 4, Publication Date: Nov. 2, 2014, Page: 45-50
 properties of vitamin A palmitate (VAP) from tablet matrices formulated with a poly (acrylic) acid polymer, Carbopol 971 (CP 971) were investigated in vitro. Formulations containing Carbopol 971 at concentrations of 10, 20, 30 and 40 % w/w were wet granulated using ethanol 95% v/v. Micromeritic evaluation of the dried granules, tablet characterization and drug dissolution studies were done in 0.05 M phosphate buffer(containing Triton X – 100®), simulated intestinal fluid (SIF) and simulated gastric fluid (SGF) without enzymes. Results obtained showed a burst release of VAP within 60 min (1 h) of the test followed by a slow retardation of VAP release over the next 7 h as the concentration of the CP 971 increased indicating SR activity. Dissolution of vitamin A palmitate was higher in the 0.05 M phosphate buffer than in SIF and SGF. The release kinetics involved mixed order while release mechanism was dominantly diffusion controlled (Fickian or Case I).&picture=http://www.aascit.org/aascit/decorators/img/journal/922.jpg)
| [1] | Nkemakolam Nwachukwu, Department of Pharmaceutics & Pharmaceutical Technology, University of Port Harcourt, Choba, Rivers State, Nigeria. |
| [2] | Martins O. Emeje, Department of Pharmaceutical Technology & Raw Material Development, National Institute For Pharmaceutical Research & Development, Idu, Abuja, Nigeria. |
| [3] | Sabinus I. Ofoefule, Department of Pharmaceutical Technology & Industrial Pharmacy, University of Nigeria, Nsukka, Enugu State, Nigeria. |
The sustained release (SR) properties of vitamin A palmitate (VAP) from tablet matrices formulated with a poly (acrylic) acid polymer, Carbopol 971 (CP 971) were investigated in vitro. Formulations containing Carbopol 971 at concentrations of 10, 20, 30 and 40 % w/w were wet granulated using ethanol 95% v/v. Micromeritic evaluation of the dried granules, tablet characterization and drug dissolution studies were done in 0.05 M phosphate buffer(containing Triton X – 100®), simulated intestinal fluid (SIF) and simulated gastric fluid (SGF) without enzymes. Results obtained showed a burst release of VAP within 60 min (1 h) of the test followed by a slow retardation of VAP release over the next 7 h as the concentration of the CP 971 increased indicating SR activity. Dissolution of vitamin A palmitate was higher in the 0.05 M phosphate buffer than in SIF and SGF. The release kinetics involved mixed order while release mechanism was dominantly diffusion controlled (Fickian or Case I).
Keywords
Sustained Release, Micromeritic, Spectrophotometric, Carbopol 971, Vitamin A Palmitate
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