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Vol.1 , No. 1, Publication Date: Jul. 7, 2014, Page: 6-11
 as a matrix in the formulation of oral sustained release (SR) tablets of theophylline hydrate was carried out. Carbopol 971 was employed as matrix in the concentration range of 10 to 40 % w/w. The matrix tablets were prepared by the wet granulation method with 95% v/v ethanol as the dispersing fluid. Dissolution rate studies on the tablets were carried out over an 8 h period in three media of 0.1 N Hydrochloric acid (HCl, pH 1.2), simulated gastric fluid, (SGF, pH 1.3) without pepsin and simulated intestinal fluid (SIF, pH 7.2) without pancreatin. There was significant retardation of drug release in all three media as the polymer concentration increased. A burst release was achieved within 60 min (1 h), after which there was a gradual and sustained release of the drug over 7 h. Theophylline release was faster in the alkaline medium (SIF) than in the acidic media (0.1 N HCl and SGF). The mechanism of release of the formulations at all concentrations of the polymer matrix was dominantly diffusion controlled (Fickian or Case I).&picture=http://www.aascit.org/aascit/decorators/img/journal/922.jpg)
| [1] | Nwachukwu, N., Department of Pharmaceutics & Pharmaceutical Technology, University of Port Harcourt, Choba, Rivers State, Nigeria. |
| [2] | Emeje, M. O., Department of Pharmaceutical Technology, National Institute for Pharmaceutical Research & Development, Idu, Abuja, Nigeria. |
| [3] | Ofoefule, S. I., Department of Pharmaceutical Technology and Industrial Pharmacy, University of Nigeria, Nsukka, Enugu State, Nigeria. |
An in vitro study on the application of Carbopol 971 (CP 971) as a matrix in the formulation of oral sustained release (SR) tablets of theophylline hydrate was carried out. Carbopol 971 was employed as matrix in the concentration range of 10 to 40 % w/w. The matrix tablets were prepared by the wet granulation method with 95% v/v ethanol as the dispersing fluid. Dissolution rate studies on the tablets were carried out over an 8 h period in three media of 0.1 N Hydrochloric acid (HCl, pH 1.2), simulated gastric fluid, (SGF, pH 1.3) without pepsin and simulated intestinal fluid (SIF, pH 7.2) without pancreatin. There was significant retardation of drug release in all three media as the polymer concentration increased. A burst release was achieved within 60 min (1 h), after which there was a gradual and sustained release of the drug over 7 h. Theophylline release was faster in the alkaline medium (SIF) than in the acidic media (0.1 N HCl and SGF). The mechanism of release of the formulations at all concentrations of the polymer matrix was dominantly diffusion controlled (Fickian or Case I).
Keywords
Theophylline Hydrate, Carbopol 971, Dissolution Studies, Sustained Release, In vitro, Matrix
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