ISSN: 2375-3900
American Journal of Pharmacy and Pharmacology  
Manuscript Information
 
 
Protective Effect of Bisphosphonates on the Pathological Changes in the Blood and Tissues in Case of Experimental Atherosclerosis
American Journal of Pharmacy and Pharmacology
Vol.3 , No. 3, Publication Date: May 13, 2016, Page: 14-19
2426 Views Since May 13, 2016, 1147 Downloads Since May 13, 2016
 
 
Authors
 
[1]    

Yurieva Eleonora Alexandrovna, The Laboratory of General Pathology, Research Clinical Institute of Pediatrics, Moscow, Russia.

[2]    

Novikova Natalia Nicolaevna, The Laboratory of X-ray Studies of Bioorganic Nanostructures Laboratory, National Research Center “Kurchatov Institute”, Moscow, Russia.

[3]    

Sukhorukov Vladimir Sergeevich, The Laboratory of General Pathology, Research Clinical Institute of Pediatrics, Moscow, Russia.

[4]    

Kushnareva Maria Vasilievna, The Laboratory of General Pathology, Research Clinical Institute of Pediatrics, Moscow, Russia.

[5]    

Vozdvizhenskaya Ekaterina Sergeevna, The Laboratory of General Pathology, Research Clinical Institute of Pediatrics, Moscow, Russia.

[6]    

Murashev Arkady Nicolaevich, The Biological Testing Laboratory, Institute of Bioorganic Chemistry Named, of Academicians M. M. Shemyakin and Y. A. Ovchinnikov, of Russian Academy of Sciences, Moscow Region, Russia.

 
Abstract
 

The protective effect of the three bisphosphonates, synthesized in Russia, on the pathological changes in the blood vessels and tissues in experimental atherosclerosis were determined. Atherosclerotic pathology was reproduced on white outbreed rats with the help of 1% cholesterol diet, sub-toxic doses of vitamin D2 and the line implantation into the abdominal aorta. The protective effect of xydifon (K, Na-etidronate), mediphone (olpadronate) and zoledronate, administered per os was studied. The positive effect of all three preparations in comparison with the untreated control was noted. There were observed the reduction of LDL, accumulation, cholesterol of triglycerides, atherogenic index and toxicity index for albumin, uric acid in the blood. The positive biochemical features were correlated with the morphological image: bisphosphonates significantly reduced the accumulation of Fe, Cu in the aortic wall and deposition of calcium granules. The usefulness of bisphosphonates in the atherosclerosis’ treatment complex is discussing.


Keywords
 

Xydifon, Bishosphonates, Atherosclerosis, Atheroma, Prophylaxis, Experiment, Laboratory Rats


Reference
 
[01]    

Titov V. N. Primary and secondary atherosclerosis, atheromatosis and atherothrombosis. M: Tver, 2008, 250.

[02]    

Titov V. N., Shiryaeva J. K. Arteriosclerosis and atherosclerosis. Pathology proximal and distal arterial bed. Pathogenesis of diabetic microangiopathy. Klin.lab.diagn. 2011, 4: 3-13.

[03]    

Titov V. N. Phylogenetic theory of general pathology. Atherosclerosis. M: »Infra-M», 2015, 237.

[04]    

Kontush A., Chapman M. J. Functionally defective high-density lipoprotein: a new therapeutic target at the crossroads of dyslipidemia, inflammation, and atherosclerosis. Pharmacol. Rev. 2006, 3: 342–374.

[05]    

Gajda M., Banas K., Banas A. et al. Distribution of selected elements in atherosclerotic plaque of apoE/LDLR-doube knockout mice assessed by synchron radiation-induced micro-XRF spectrometry. X-Ray Spectron 2008, 37: 495-502.

[06]    

Gajda M., Kowalska J., Banas A., Banas K., et al. Distribution of selected elements in atheroscltrotic plaqes in apoe/LDLR-double knockout mice subjected to dietary and pharmacological treatments. Synchrotron Radiation in Natur. Science. 2010, 9: 1-2: 114.

[07]    

Yuryeva E. A., Sukhorukov V. S., Vozdvizhenkay E. S., Novikova N. N. Atherosclerosis: Hypotheses and theories. Ross.vestn.perinatologii and Pediatrics 2014, 59: 3: 6-16.

[08]    

Watt F., Rajendran R., Ren M. Q., et al. A nuclear microscopy study of trace elements Ca, Fe, Zn and Cu in ateroscltrosis. Nuclear instr. and method in Physics Res. 2006, B 249: 646-652.

[09]    

Abdelhaim M. Atherosclerosis can bestrongly influenced by iron and Zn overload or deficiency in the lung and Kidney tissues of rabbits. African J. Microb. Res., 2010, 4: (24): 2748–53.

[10]    

Debernardi N., Roijers R., Krams R. et al. Microcalcifications in atherosclerotic lesion of apolipoprotein E-deficient mouse. Int. J. Exp. Path. 2010, 91: 485–94.

[11]    

Lynch S., Frei B. Mechanisms of Cu and Fe-dependent oxidative modification of human LDL. J. Lipid Res. 1993, 34 (10): 1745–53.

[12]    

Stocker J. I., Keaney J. F. Ir. Oxydative modification in atherosclerosis. Physiol. Rev., 2004, 84 (4), 1381-1478.

[13]    

Kelley E. E., Khoo N. K., Hundley N. J. et al. Hydrogen peroxide is the major oxidant product of xantine oxidase. Free Radic Biol. Med. 2010, 48 (4): 493-498.

[14]    

Sulivan J. Z. Is homocysteine an iron dependent cardiovascular risk factor? Kidney Int., 2006, 69: 642-644.

[15]    

Yuryeva E. A., Sukhorukov V. S., Murashov A. N. et al. Biochemical markers atherogenic and protective activity of ksidifon in experimental animals. Byull.eksper.biol. and Medicine, 2012, 4: 445-448.

[16]    

Skalny A. V.. Microelementoses man, M: Science World, 1999, 96.

[17]    

Fleisch H. Bisphosphonanes in bone diseases. Acad Press, 2000, 211.

[18]    

Matkovskay T. A., Popov K. I., Yuryeva E. A. Bisphosphonates. The properties, structure and medical applications. M: Chemistry, 2001, 223.

[19]    

Francis M. D., Russelle R. G. G., Fleisch H. Diphosphonates in hibit formation of calcium phosphate crystals in vitro and pathological calcification in vivo. Sciens, 1969, 165: 1264-1266.

[20]    

Francis M. D., Hovancik K., Boyce R. W. NE-58095: A diphosphonates wich prevents bone crossion and preserves joint architecture in experimental arthritis. Int/J/Tissue React., 1989, 11: 239-252.

[21]    

Novikova N. N., Kovalchuk M. V., Stepina N. D. et al. X-ray spectral-selective methods for structural diagnostics ordered bioorganic nanosystems overhnosti liquid. Poverhnost. Rentgenovskie, ineytronnye synchrotron research. 2011, 9: 6-11.

[22]    

Novikova N. N., Kovalchuk M. V., Yuryeva E. A. et al. The possibility of X-ray fluorescence measurements in terms of air defense for the study of molecular mechanisms of disorders of microelement balance in the body. Crystallography. 2012, 57 (5): 727-34.

[23]    

Novikova N., Kovalchuk M., Stepina N., Gaynutdinov R., Chukhrai E., Yurieva E. Distinct effect of xenobiotics on the metal-binding properties of protein molecules. J. Synchrotron Rad., 2015, 22:1:1001-1007.

[24]    

Yuryeva E. A., Sukhorukov V. S., Tsaregorodcev A. D. et al.. The change of protein molecules with endogenous intoxication as a risk factor for chronic metabolic diseases. Molek.med. 2013, 3: 45-52.

[25]    

Grizunov Y. A., Dobretsov G. E. Serum albumin in clinical medicine. M: "Ireus", 1994, 13-34.

[26]    

Yuryeva E. A., Dlin V. V. Diagnostic reference nephrologist. M: "Overlay", 2007, 96.

[27]    

Jenner A., Ren M., Rajendran R. et al. Zink supplementation inhibits lipid peroxidation and the development of atherosclerosis in rabbit fed a high cholesterol diet. Free Rad. Biol. Med. 2007, 42: 559–66.





 
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