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American Journal of Pharmacy and Pharmacology

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Role of Propofol on Cardiomyocyte Under Hypoxia

American Journal of Pharmacy and Pharmacology
Vol.3 , No. 4, Publication Date: Jun. 7, 2016, Page: 29-32

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Authors

[1]	Han-Fang Tseng, Division of Anesthesiology, Show Chwan Memoialy Hospital, Changhua, Taiwan, Republic of China.
[2]	Huan-Nung Chao, Division of Cardiology, Show Chwan Memoialy Hospital, Changhua, Taiwan, Republic of China.
[3]	Kuei-Feng Tsou, Division of Anesthesiology, Show Chwan Memoialy Hospital, Changhua, Taiwan, Republic of China.

Abstract

Objective: Ischemic heart disease is a leading cause of death worldwide. Moreover, there is no effective therapy for preventing myocardial ischemia-reperfusion (I/R) injury. Propofol is widely used in anesthetic and has been shown to control inflammatory response, however, the role of propofol on cardiomyocyte H9c2 under hypoxia remains to be established. Method: To speculate the effect of propofol on H9c2 cells survival under hypoxia, we used new analysis tool iCELLigence system in real time and typical WST-1 assay as approaches. Results and conclusion: Results showed that propofol reversed hypoxia-induced cardiomyocyte H9c2 cells death/ growth inhibition and decreased cell viability.

Keywords

Propofol, Cardiomyocyte, Hypoxia

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