Indexing
All Issues
Submission
Author Guidelines
Reviewers
Editorial Members
Publication Fee
Vol.3 , No. 3, Publication Date: May 19, 2016, Page: 20-28
 has been supported by several epidemiological studies. Extract of Hypericum <i>thymopsis</i> (HTE), a well known medicinal plant, is used for the treatment of depression, has been explored in the present study for its protective role against Aluminum neurotoxicity. This data suggests that HTE may be a candidate for application in neurodegenerative diseases such as Alzheimer’s disease. Results of this study demonstrate that Aluminiumneurotoxicity play an important role in the development of anxiety disorders, depression and memory deficit in mice, these alterations of behavioral activities can be a cause of development of Alzheimer’s disease. HTE possesses significant antioxidant activity and renders neuroprotection which was more pronounced at the dose of 200mg/ kg against Al induced neurotoxicity. Chronic administration of Hypericum thymopsis significantly improved retention in both tasks, attenuated oxidative damage, Aluminum concentration in Aluminum treated mice (p 0,05). Hypericum have neuropotective effects against Aluminum-induced cognitive dysfunction and oxidative damage.&picture=http://www.aascit.org/aascit/decorators/img/journal/922.jpg)
| [1] | Salima Douichene, Department of Biology, Laboratory of Pharmacognosy Api Phytotherapy, Faculty of Life and Natural Sciences, University, Mostaganem, Algeria. |
| [2] | Kheira Hammadi, Department of Biology, Laboratory of Pharmacognosy Api Phytotherapy, Faculty of Life and Natural Sciences, University, Mostaganem, Algeria. |
| [3] | Noureddine Djebli, Department of Biology, Laboratory of Pharmacognosy Api Phytotherapy, Faculty of Life and Natural Sciences, University, Mostaganem, Algeria. |
The effect of Aluminum chloride was investigated to describe the associated behavioral and brain modifications. We don’t know enough about the biological chemistry of chronic and sub- acute exposure to Aluminium to be able to predict its impact on human health. Although the hypothesis of a link between Aluminium and Alzheimer’s disease (AD) has been supported by several epidemiological studies. Extract of Hypericum thymopsis (HTE), a well known medicinal plant, is used for the treatment of depression, has been explored in the present study for its protective role against Aluminum neurotoxicity. This data suggests that HTE may be a candidate for application in neurodegenerative diseases such as Alzheimer’s disease. Results of this study demonstrate that Aluminiumneurotoxicity play an important role in the development of anxiety disorders, depression and memory deficit in mice, these alterations of behavioral activities can be a cause of development of Alzheimer’s disease. HTE possesses significant antioxidant activity and renders neuroprotection which was more pronounced at the dose of 200mg/ kg against Al induced neurotoxicity. Chronic administration of Hypericum thymopsis significantly improved retention in both tasks, attenuated oxidative damage, Aluminum concentration in Aluminum treated mice (p 0,05). Hypericum have neuropotective effects against Aluminum-induced cognitive dysfunction and oxidative damage.
Keywords
Aluminum, Alzheimer’s Disease, Hypericum Thymopsis Extract (HTE) Neuroprotection, Mice
Reference
| [01] | Yokel, R. A. and P. J. Mc Namara, 2001. Aluminum toxicokinetics: an updated minireview. Pharmacol. Toxicol; 88: 159-167. |
| [02] | Alfrey, AC; G. R. Le Gendre and W. D. Kaehny, 1976. The dialysis encephalopathy syndrome. posiible aluminum intoxication. N. Engl. J. Med; 294: 184-188. |
| [03] | Klein, G. L; 1993. Aluminum and hepatobiliary complications of total parenteral nutrition. Gastroenterology, 10: 1583-1584. |
| [04] | Ward, M. K; T. G. Feest, H. A. Ellis, I. S. Parkinson and D. N. KERR, 1978. Osteomalacic dialysis osteodystrophy: Evidence for a water-borne aetiological agent, probably aluminum. Lancet, 22: 841-845. |
| [05] | Short, A. I. K., R. J. Winney and J. S. 1980. Robson, Reversible microcytic hypochromic anaemia in dialysis patients due to aluminum intoxication. Proc. Eur. Dial. Transplant. Assoc; 17: 226-233. |
| [06] | Yamada K, Nabeshima T. Animal models of Alzheimer’s disease and evaluation of anti-dementia drugs. Pharmacol Therapeut 2000; 88: 93-113. |
| [07] | Robson, N. "Studies in the genus Hypericum L. (Clusiaceae). 1 Section 9. Hypericum sensu lato (part 3): subsection 1. Hypericum series 2. Senanensia, subsection 2. Erecta and section 9b. Graveolentia. 2006" Systematics and Biodiversity 4: 19-98. |
| [08] | Spiteller M, Ozen T, Smelcerovic A, Zuehlke S, Mimica-Dukic N. Phenolic constituents and the in vitro antioxidant activity of the flowers of H. venustum. Fitoterapia 79 (3): 191-193. 2008. |
| [09] | Green, R. J. and M. E. Stanton, 1989. Differential ontogeny of working memory and reference memory in the rat. Behav. Neurosci; 103: 98-105. |
| [10] | Schenk, F. and R. G. Morris, 1985. Between components of spatial memory in rats after recovery from the effects of retrohippocampal lesions. Exp. Brain Res; 58: 11-28. |
| [11] | Boissier, J. R. and P. Simon, 1962. The exploration reaction in the mouse. Preliminary note. Therapie; 17: 1225-1232. |
| [12] | Costall, B., M. E. Kelly, R. J. Naylor and E. S. Onaivi, 1989. The effects of ondansetron (GR38032F) in rats and mice treated subchronically with diazepam. Pharmacol. Biochem. Behav; 32: 777-785. |
| [13] | Persolt, R. D; A. Bertin and M. Jalfre, 1977. Behavioral despair in mice: a primary screening test for antidepressants; Arch. Int. Pharmacodyn. Ther; 229: 327-336. |
| [14] | Pan R, Qiu S, Lu DX, Dong J. “Curcumin improves learning and memory ability and its neuroprotective mechanism in mice” Chin Med J (Engl). 2008 May 5; 121 (9): 832-9. |
| [15] | Morris, R. G. and A. D. Baddeley, 1988. Primary and working memory functioning in Alzheimer-type dementia. J. Clin. Exp. Neuropsychol; 10: 279-296. |
| [16] | Golub, M. S.; Keen CL., Gershwin ME. Neurodevelopemental effect of aluminium in mice: forstering studies. Neurotoxicol teratol 14: 177-182 1992. |
| [17] | Anil Kumar; Samrita Dogra; Atish Prakash “protective effect of curcumin (curcuma longa), against aluminium toxicity: possible behavioral and biochemical alteration in rats. Behavioural Brain research 205 (2009) 384-390. |
| [18] | Gourier-Fréry C, Fréry N, Berr C, CordierS, Garnier R, Isnard H, et al. Aluminium. Quels risques pour la santé? Synthèse des études épidémiologiques. Volet épidémi-ologique de l’expertise collective INVS-Afssa-Afssaps. InstitutdeVeilleSanitaire; novembre2004, 270p. |
| [19] | Rebai Ouafa and Nour Eddine Djebli “Chronic Exposure to Aluminum Chloride in Mice: Exploratory Behaviors and Spatial Learning” Advances in Biological Research 2 (1-2): 2008. |
| [20] | Costall, B., M. E. Kelly, R. J. Naylor and E. S. Onaivi, 1989. The effects of ondansetron (GR38032F) in rats and mice treated subchronically with diazepam. Pharmacol. Biochem. Behav., 32: 777-785. |
| [21] | Sahin, G., Varol, I. and Temizer, A., Determination of aluminum levels in the kidney, liver and brain of mice treated with aluminumhydroxide, Biol. Trace. Elem. Res., 41: 129-135 (1994). |
| [22] | Gardier, A. M. and M. Bourin, Appropriate use of "knockout" mice as models of depression or models of testing the efficacy of antidepressants. Psychopharmacology, 153: 393-4. 2001. |
| [23] | Santucci D., Judith Rankin., Giovanni Laviola., Luiji Aloe., Section of behavioral pathophysiology, Lab. Di Fisiopatologia di Organo edi sistima, Istitute superior di sanita, vial Regina Elena 299,1-00161, Roma, Ilaly b Institue of cell, Animal and population Biology, King’s buildings, west Mains road, Edinburgh EH9 3JT, UKc Istituto di Neurobiologia, NR, vial Carlo Marx 15,1-00155, Roma, Italy (5 March 2003). |
| [24] | Luo Y, Nie J, Gong Q. H, Lu Y. F, Wu Q, Shi J. S: Protective effcts of icarin against learning and memory deficits induced by aluminum in rats; Clin. Exp. Pharmacol. Physiol. 2007 Aug; 34 (8): 792-795. |
