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Vol.2 , No. 4, Publication Date: Aug. 22, 2015, Page: 28-34
. The granules were fractionated from three sieve fractions (1.0, 0.5 and 0.25 mm). Granule properties evaluated as a function of the particle size are hopper flow rate, angle of repose, bulk and tapped densities, Hausner’s quotient and Carr’s index. The effects of the particle size fractions on the mechanical properties of the tablets (crushing strength and friability) and on the <i>in vitro</i> release profile of metronidazole was also investigated. Results obtained indicated that decrease in particle size improved the <i>in vitro</i> release profile of metronidazole and caused a gradual decrease in the mechanical properties of the tablets. The projected <i>in vivo</i> bioavailability of metronidazole using the dissolution efficiency parameter (DE) showed an increase in DE with a decrease in the particle size.&picture=http://www.aascit.org/aascit/decorators/img/journal/922.jpg)
| [1] | Umeh O. N. C., Drug Delivery and Nanotechnology Research Unit, Department of Pharmaceutical Technology and Industrial Pharmacy, University of Nigeria, Nsukka, Enugu State, Nigeria. |
| [2] | Ekeugo U. E., Department of Pharmaceutical Technology and Industrial Pharmacy, University of Nigeria, Nsukka, Enugu State, Nigeria. |
| [3] | Ofoefule S. I., Drug Delivery and Nanotechnology Research Unit, Department of Pharmaceutical Technology and Industrial Pharmacy, University of Nigeria, Nsukka, Enugu State, Nigeria. |
Properties of a tablet such as the mechanical properties, disintegration time and drug release characteristics have been found to be affected by particle size, the properties of the added excipient and the manufacturing process employed in formulation. The aim of the present work was to investigate the effect of particle size on the mechanical properties and in vitro release profile of metronidazole from compressed tablets. Three tablet batches were prepared by the wet granulation method using different formulation components (binders, disintegrants and fillers). The granules were fractionated from three sieve fractions (1.0, 0.5 and 0.25 mm). Granule properties evaluated as a function of the particle size are hopper flow rate, angle of repose, bulk and tapped densities, Hausner’s quotient and Carr’s index. The effects of the particle size fractions on the mechanical properties of the tablets (crushing strength and friability) and on the in vitro release profile of metronidazole was also investigated. Results obtained indicated that decrease in particle size improved the in vitro release profile of metronidazole and caused a gradual decrease in the mechanical properties of the tablets. The projected in vivo bioavailability of metronidazole using the dissolution efficiency parameter (DE) showed an increase in DE with a decrease in the particle size.
Keywords
Particle Size Fractions, Micromeritic Properties, Mechanical Properties, In vitro Release, Metronidazole, Dissolution Efficiency
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