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Vol.2 , No. 3, Publication Date: Aug. 7, 2015, Page: 13-20
&description=A study of the physico-technical properties of a novel co-processed multicomponent Lentinus tuber regium (LTR) based excipient (fizlent) designed to improve flowability and compressibility of LTR was carried out. A wet mass obtained by solvent evaporation of alcoholic dispersions of LTR, sodium bicarbonate, tartaric and citric acids in proportions of 80, 10, 6.5, 3.5 % w/w respectively was granulated, dried at 60º C and classified with 250µm sieve. Densities (bulk, tapped and particle), flow properties (flow rate, angle of repose, Carr’s index, Hausner’s ratio), swelling index, hydration capacity, differential scanning calorimetry (DSC), scanning electron microscopy (SEM) and pH were determined for the natural, processed LTR and fizlent. Fizlent appeared as a compactable, tasteless, off-white powder without distinct odour. Aqueous dispersion of it has pH of 6.92 ± 0.13. Results show that a new pharmaceutical grade co-processed excipient, fizlent with enhanced flow, compressibility and dilution potential of 70-80% (paracetamol) and ≤ 30% for metronidazole, ascorbic acid and ibuprofen respectively was developed by particle engineering of Lentinus tuber regium, citric acid, tartaric acid and sodium hydrogen carbonate. Fizlent may be a useful filler-binder with potentials as directly compressible powder especially for most low dose drugs and may possibly serve as superdisintegrant.&picture=http://www.aascit.org/aascit/decorators/img/journal/922.jpg)
| [1] | Ugoeze K. C., Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, University of Port Harcourt, Port Harcourt, Nigeria. |
| [2] | Nkoro V. O., Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, University of Port Harcourt, Port Harcourt, Nigeria. |
A study of the physico-technical properties of a novel co-processed multicomponent Lentinus tuber regium (LTR) based excipient (fizlent) designed to improve flowability and compressibility of LTR was carried out. A wet mass obtained by solvent evaporation of alcoholic dispersions of LTR, sodium bicarbonate, tartaric and citric acids in proportions of 80, 10, 6.5, 3.5 % w/w respectively was granulated, dried at 60º C and classified with 250µm sieve. Densities (bulk, tapped and particle), flow properties (flow rate, angle of repose, Carr’s index, Hausner’s ratio), swelling index, hydration capacity, differential scanning calorimetry (DSC), scanning electron microscopy (SEM) and pH were determined for the natural, processed LTR and fizlent. Fizlent appeared as a compactable, tasteless, off-white powder without distinct odour. Aqueous dispersion of it has pH of 6.92 ± 0.13. Results show that a new pharmaceutical grade co-processed excipient, fizlent with enhanced flow, compressibility and dilution potential of 70-80% (paracetamol) and ≤ 30% for metronidazole, ascorbic acid and ibuprofen respectively was developed by particle engineering of Lentinus tuber regium, citric acid, tartaric acid and sodium hydrogen carbonate. Fizlent may be a useful filler-binder with potentials as directly compressible powder especially for most low dose drugs and may possibly serve as superdisintegrant.
Keywords
Physico-Technical, Multicomponent, Lentinus tuber regium, Co-processed, Excipient, fizlent
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