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American Journal of Pharmacy and Pharmacology

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Antidepressant Effect of Petroleum Ether Extract of Malkangni (Celastrus Paniculatus) in Rats and Mice

American Journal of Pharmacy and Pharmacology
Vol.2 , No. 2, Publication Date: Apr. 10, 2015, Page: 9-12

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Authors

[1]	Feroz A. Wani, Department of Ilmul Advia (Pharmacology), Facility of Medicine (Unani), Jamia Hamdard, New Delhi, India.
[2]	Arsheed Iqbal, RRIUM/CCRUM, Hazratbal, Srinagar (J&K), India.
[3]	Afroza Jan, RRIUM/CCRUM, Hazratbal, Srinagar (J&K), India.
[4]	M. A. Jafri, Department of Ilmul Advia (Pharmacology), Facility of Medicine (Unani), Jamia Hamdard, New Delhi, India.

Abstract

The present study was designed to evaluate the antidepressant effect of petroleum ether extract of seeds of Malkangni (Celastrus paniculatus) in rats and mice. The petroleum ether extract was found to reduce the immobility period in forced swimming test and tail suspension test and reverse the reserpine induced extension of immobility in mice. Similar to Imipramine (IMI), the test drug extract reversed the degree of ptosis and catalepsy induced by reserpine in rats. The effects exhibited were dose dependent. These results suggest that the drug possesses antidepressant activity, the mechanism of action and the ingredients responsible for the action, however, remains to be elucidated.

Keywords

Celastrus Peniculatus, Antidepressant Effect, Petroleum Ether Extract, Catalepsy, Reserpine

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