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Vol.1 , No. 2, Publication Date: Jul. 18, 2014, Page: 19-24
 Phenotype among Pregnant Women in Sokoto, North Western Nigeria. Implications on Haemolytic Disease of the New-Born and Haemolytic Transfusion Reaction&description=This study investigated the prevalence of Rhesus D antigens among pregnant women in Sokoto, North Western, Nigeria. A total of 155 blood samples from pregnant women aged 18 to 45 years and mean age 27.19 ± 4.70 years attending ANC in UDUTH Sokoto were tested for Rh(D) phenotype using Lorne Laboratories of UK Anti-D reagent. Out of 155 subjects tested, 144 (92.9%) were Rh (D) positive while 11(7.1%) were Rhesus (D) negative. The prevalence of Rh D positive phenotype was highest among the Yoruba ethnic group (100%) and lowest among the Ibo ethnic group (83.3%). The prevalence of Rh D negative phenotype was highest among the Hausa ethnic group (42.5%) and lowest among the Yoruba ethnic group (0%). Antibodies to Rhesus D antigens can cause haemolytic disease of the foetus new-born and haemolytic transfusion reaction. Pregnant women should be tested routinely for their Rhesus D phenotypes as well as for the presence of clinically significant alloantibodies during pregnancy. Facilities for the demonstration of FMH should be made available in laboratories in Nigeria. Healthcare staff looking after Rh (D) negative women should be trained on anti-D prophylaxis. Universal access to prophylactic anti-D should be provided for all Rh (D) negative women. Rh (D) negative women who are to have a termination of pregnancy or who suffer from miscarriages or any other potentially sensitizing events during pregnancy should be offered immunoglobin D as a prophylactic measure to prevent alloimmunization.&picture=http://www.aascit.org/aascit/decorators/img/journal/908.jpg)
| [1] | Erhabor O., Department of Haematology and Transfusion Science, Faculty of Medical Laboratory Science, Usmanu Danfodiyo University, Sokoto, Nigeria. |
| [2] | Kabiru Salisu Adamu, Department of Haematology and Transfusion Science, Faculty of Medical Laboratory Science, Usmanu Danfodiyo University, Sokoto, Nigeria. |
| [3] | Yakubu A., Department of Obstetrics and Gynaecology Usmanu Danfodiyo University, Sokoto, Nigeria. |
| [4] | Shehu C. E., Department of Obstetrics and Gynaecology Usmanu Danfodiyo University, Sokoto, Nigeria. |
| [5] | Hassan M., Department of Obstetrics and Gynaecology Usmanu Danfodiyo University, Sokoto, Nigeria. |
| [6] | Singh S., Department of Obstetrics and Gynaecology Usmanu Danfodiyo University, Sokoto, Nigeria. |
This study investigated the prevalence of Rhesus D antigens among pregnant women in Sokoto, North Western, Nigeria. A total of 155 blood samples from pregnant women aged 18 to 45 years and mean age 27.19 ± 4.70 years attending ANC in UDUTH Sokoto were tested for Rh(D) phenotype using Lorne Laboratories of UK Anti-D reagent. Out of 155 subjects tested, 144 (92.9%) were Rh (D) positive while 11(7.1%) were Rhesus (D) negative. The prevalence of Rh D positive phenotype was highest among the Yoruba ethnic group (100%) and lowest among the Ibo ethnic group (83.3%). The prevalence of Rh D negative phenotype was highest among the Hausa ethnic group (42.5%) and lowest among the Yoruba ethnic group (0%). Antibodies to Rhesus D antigens can cause haemolytic disease of the foetus new-born and haemolytic transfusion reaction. Pregnant women should be tested routinely for their Rhesus D phenotypes as well as for the presence of clinically significant alloantibodies during pregnancy. Facilities for the demonstration of FMH should be made available in laboratories in Nigeria. Healthcare staff looking after Rh (D) negative women should be trained on anti-D prophylaxis. Universal access to prophylactic anti-D should be provided for all Rh (D) negative women. Rh (D) negative women who are to have a termination of pregnancy or who suffer from miscarriages or any other potentially sensitizing events during pregnancy should be offered immunoglobin D as a prophylactic measure to prevent alloimmunization.
Keywords
Rhesus (D) Phenotype, Pregnant Women, Sokoto, Nigeria, Haemolytic Disease of the New-Born, Haemolytic Transfusion Reaction
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