Indexing
All Issues
Submission
Author Guidelines
Reviewers
Editorial Members
Publication Fee
Vol.2 , No. 5, Publication Date: Aug. 22, 2015, Page: 68-72
:20 volunteers received an inert substance (500mg starch capsule) daily for five consecutive days. Group II (treated group):25 volunteers received 500 mg Ginger daily for five consecutive days. Before taking the treatment and placebo pre-treatment scores were measured, then soon after completing these measurements a post-treatment score were measured daily. Leeds psychomotor battery tester is a device that measured psychomotor performance, vigilance status and critical flicker fusion frequency was used in the present study. Results: Placebo, produced an insignificant effect (<i>p</i>>0.05) on all vigilance variables after five days of therapy with starch capsule 500mg/day, except for MRT placebo; demonstrated significant effects <i>p</i>=0.04, Ginger 500mg/day for five days lead to significant activation of most vigilance variables <i>p</i><0.05 except on critical flicker frequency it produced insignificant effect <i>p</i>=0.08. Conclusion: Ginger improves psychomotor performances and vigilance task in normal healthy volunteers.&picture=http://www.aascit.org/aascit/decorators/img/journal/907.jpg)
| [1] | Hayder M. Al-Kuraishy, Department of Clinical Pharmacology and Therapeutic, Medical Faculty, College of Medicine, Al-Mustansiriya University, Baghdad, Iraq. |
Background: Ginger and its active constituents play an important and vital role in neuroprotection and acceleration of brain functions mainly via shogaol active ingredient which prevents transient cerebral ischemia, antioxidant effect and up-regulation of antioxidant enzyme levels. Aim: The aim of the present study was to elucidate and evaluation of Ginger in young human vigilance and psychomotor performance. Subjects and Methods: Forty five healthy volunteers with age ranged from 21-23 years were recruited into this pilot study. The volunteers were divided into two groups, group I (placebo group):20 volunteers received an inert substance (500mg starch capsule) daily for five consecutive days. Group II (treated group):25 volunteers received 500 mg Ginger daily for five consecutive days. Before taking the treatment and placebo pre-treatment scores were measured, then soon after completing these measurements a post-treatment score were measured daily. Leeds psychomotor battery tester is a device that measured psychomotor performance, vigilance status and critical flicker fusion frequency was used in the present study. Results: Placebo, produced an insignificant effect (p>0.05) on all vigilance variables after five days of therapy with starch capsule 500mg/day, except for MRT placebo; demonstrated significant effects p=0.04, Ginger 500mg/day for five days lead to significant activation of most vigilance variables p<0.05 except on critical flicker frequency it produced insignificant effect p=0.08. Conclusion: Ginger improves psychomotor performances and vigilance task in normal healthy volunteers.
Keywords
Ginger, Vigilance, Psychomotor Performance
Reference
| [01] | Mahmoudi GA, Almasi V, Lorzadeh N, Khansari A. The reasons for using and not using alternative medicine in Khorramabad women, west of Iran. J Pak Med Assoc. 2015 Jun;65(6):623-5 |
| [02] | GiesbrechtT, Rycroft JA, Rowson MJ, De Bruin EA. The combination of L-theanine and caffeine improves cognitive performance and increases subjective alertness. NutrNeurosci. 2010 Dec; 13(6): 283-90. |
| [03] | KannappanR, Gupta SC, Kim JH, Reuter S, Aggarwal BB. Neuroprotection by spice-derived nutraceuticals: you are what you eat!MolNeurobiol. 2011 Oct;44(2):142-59. |
| [04] | Prasad S, Tyagi AK. Ginger and its constituents: role in prevention and treatment of gastrointestinal cancer. Gastroenterol Res Pract. 2015; 2015: 142979. |
| [05] | Ha SK, Moon E, Ju MS, Kim DH, Ryu JH, Oh MS, et al. 6-Shogaol, a ginger product, modulates neuroinflammation: a new approach to neuroprotection.Neuropharmacology. 2012 Aug;63(2):211-23. |
| [06] | Park G, Kim HG, Ju MS, Ha SK, Park Y, Kim SY, et al. 6-Shogaol, an active compound of ginger, protects dopaminergic neurons in Parkinson's disease models via anti-neuroinflammation.ActaPharmacol Sin. 2013 Sep;34(9):1131-9. |
| [07] | Swomley AM, Butterfield DA. Oxidative stress in Alzheimer disease and mild cognitive impairment: evidence from human data provided by redox proteomics. Arch Toxicol. 2015 Jul 1. |
| [08] | JittiwatJ, Wattanathorn J. Ginger pharmacopuncture improves cognitive impairment and oxidative stress following cerebral ischemia. J Acupunct Meridian Stud. 2012 Dec; 5(6):295-300. |
| [09] | Morioka H, Kanemura A, Morimoto S, Yoshioka T, Oba S, Kawanabe M, et al. Decoding spatial attention by using cortical currents estimated from electroencephalography with near-infrared spectroscopy prior information.Neuroimage. 2014 Apr 15; 90: 128-39. |
| [10] | Kline CE, Durstine JL, Davis JM, Moore TA, Devlin TM, Youngstedt SD. Circadian rhythms of psychomotor vigilance, mood, and sleepiness in the ultra-short sleep/wake protocol. Chronobiol Int. 2010 Jan; 27(1):161-80. |
| [11] | Moskowitz H. Attention tasks as skills performance measures of drug effects. Br J ClinPharmacol. 1984; 18Suppl 1:51S-61S. |
| [12] | Lim S, Moon M, Oh H, Kim HG, Kim SY, Oh MS. Ginger improves cognitive function via NGF-induced ERK/CREB activation in the hippocampus of the mouse. J NutrBiochem. 2014 Oct; 25(10):1058-65. |
| [13] | Waggas AM. Neuroprotective evaluation of extract of ginger (Zingiberofficinale) root in monosodium glutamate-induced toxicity in different brain areas male albino rats. Pak J Biol Sci. 2009 Feb 1; 12(3):201-12. |
| [14] | Rungsaeng P, Sangvanich P, Karnchanatat A.Zingipain, a ginger protease with acetylcholinesterase inhibitory activity. Appl Biochem Biotechnol. 2013 Jun; 170(4):934-50. |
| [15] | Gregoriou GG, Rossi AF, Ungerleider LG, Desimone R. Lesions of prefrontal cortex reduce attentional modulation of neuronal responses and synchrony in V4. Nat Neurosci. 2014 Jul;17(7):1003-11. |
| [16] | Saenghong N, Wattanathorn J, Muchimapura S, Tongun T, Piyavhatkul N, Banchonglikitkul C, et al. Zingiber officinale Improves Cognitive Function of the Middle-Aged Healthy Women.Evid Based Complement Alternat Med. 2012;2012:383062. |
| [17] | Huang CF, Yang RS, Liu SH, Hsieh PC, Lin-Shiau SY. Evidence for improved neuropharmacological efficacy and decreased neurotoxicity in mice with traditional processing of Rhizoma Arisaematis. Am J Chin Med. 2011; 39(5):981-98. |
| [18] | Wattanathorn J, Jittiwat J, Tongun T, Muchimapura S, Ingkaninan K. Zingiberofficinale Mitigates Brain Damage and Improves Memory Impairment in Focal Cerebral Ischemic Rat.Evid Based Complement Alternat Med. 2011;2011:429505. |
| [19] | Chen Y, Curran CP, Nebert DW, Patel KV, Williams MT, Vorhees CV. Effect of vitamin C deficiency during postnatal development on adult behavior: functional phenotype of Gulo-/- knockout mice.Genes Brain Behav. 2012 Apr;11(3):269-77. |
| [20] | Someya A, Horie S, Yamamoto H, Murayama T. Modifications of capsaicin-sensitive neurons in isolated guinea pig ileum by 6-gingerol and lafutidine. J Pharmacol Sci. 2003 Aug;92(4):359-66. |
| [21] | Vaibhav K, Shrivastava P, Tabassum R, Khan A, Javed H, Ahmed ME, et a. Delayed administration of zingerone mitigates the behavioral and histological alteration via repression of oxidative stress and intrinsic programmed cell death in focal transient ischemic rats.Pharmacol Biochem Behav. 2013 Nov 15; 113:53-62. |
| [22] | Klugman A, Naughton DP, Isaac M, Shah I, Petroczi A, Tabet N.Antioxidant enzymatic activities in Alzheimer's disease: the relationship to acetylcholinesterase inhibitors. J Alzheimers Dis. 2012; 30(3):467-74. |
| [23] | Nogueira de Melo GA, Grespan R, Fonseca JP, Farinha TO, da Silva EL, Romero AL, et al. Inhibitory effects of ginger (Zingiberofficinale Roscoe) essential oil on leukocyte migration in vivo and in vitro. J Nat Med. 2011 Jan; 65(1):241-6. |
| [24] | Silasi G, Kolb B. Chronic inhibition of cyclooxygenase-2 induces dendritic hypertrophy and limited functional improvement following motor cortex stroke. Neuroscience. 2007 Feb 23; 144(4):1160-8. Epub 2006 Dec 15. |
