ISSN: 2375-3765
American Journal of Chemistry and Application  
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Solid - Solid Syntheses of Bisindolylmethane in Reciprocating Reactor
American Journal of Chemistry and Application
Vol.6 , No. 3, Publication Date: Jun. 11, 2019, Page: 25-37
1111 Views Since June 11, 2019, 403 Downloads Since Jun. 11, 2019
 
 
Authors
 
[1]    

Zahra Ebadi, Transport Phenomena Research Centre, Sahand University of Technology, Tabriz, Iran.

[2]    

Jafarsadegh Moghaddas, Transport Phenomena Research Centre, Sahand University of Technology, Tabriz, Iran.

 
Abstract
 

3,3'-Bis-indolyl-(3-nitrophenyl)methane and 3,3'-Bis-indolyl-(4-chlorophenyl)methane were synthesized in reactor condition in this study. The impact of various factors on the yield including: time, frequency, ball and number of balls, were investigated. Investigations showed that frequency was the most effective in the useful production. Four two-millimeter balls at different stages and one, two, three and four balls were used in sequence. Yield increased by increasing number of ball to three, but with the addition of the fourth ball efficiency decreased. In general, it was observed that at the same time, frequency and number of balls, the yield of reaction between indole and 3-nitrobenzaldehyde was more than indole and 4-cholorobenzaldehyde. At a frequency of 8 Hz, 8 minutes and 3 balls, the reaction yield of indole and 3-nitrobenzaldehyde was about 72% and the reaction yield of indole and 4-cholorobenzaldehyde was about 70%. The resulting product was pink that corresponded with the references. The melting point for 3,3'-Bis-indolyl-(3-nitrophenyl)methane was measured 220°C that it has been reported in the literature in the range of 219-221°C. Indole and 4-cholorobenzaldehyde reaction product melting point was measured about 70°C that the reported amount for 3,3'-Bis-indolyl- (4-chloro phenyl) methane in the literature is about 76-77°C.


Keywords
 

Frequency, Ball, Indole, 4-chloro-benzaldehyde, 3-nitro-benzaldehyde, Bisindolylmethane


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