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Vol.4 , No. 4, Publication Date: Aug. 25, 2017, Page: 21-25
 C. D. Adams&description=<i>Aspilia africana</i> (Pers.) C. D. Adams, an indigenous Nigerian plant belongs to the phylum Tracheophyta in the family Asteraceae. Investigation into the hot aqueous leaves extract revealed the presence of phytochemicals such as tannins, saponins, flavonoids and glycosides. Alkaloids were however absent. Examination of the roots also gave a brown oil which was identified by its spectra data such as infra-red, mass, proton and <sup>13</sup>C nmr spectra as a furofuranoid lignan (5). Evidence of this comes from the presence of the diagnostic features of the furofurans which include the benzylic protons signal at δ4.50 as a doublet (J=7), the methylene protons at δ3.56 as double doublet (J=5; 10) and the methine protons at δ2.86 as multiplets. The structure of (5) was confirmed by synthesis using ethyl piperonoyl acetate (1). Comparison of the spectra of the naturally occurring compound (5) with that of the synthetic one confirmed that both compounds are the same.&picture=http://www.aascit.org/aascit/decorators/img/journal/905.jpg)
| [1] | Ibiba Reuben Jack, Department of Chemistry, Rivers State University, Nkpolu-Oroworukwo, Port Harcourt, Nigeria. |
| [2] | Gloria Ihuoma Ndukwe, Department of Chemistry, Rivers State University, Nkpolu-Oroworukwo, Port Harcourt, Nigeria. |
| [3] | Prince Joe Nna, Department of Chemistry, Ignatius Ajuru University of Education, Port Harcourt, Nigeria. |
Aspilia africana (Pers.) C. D. Adams, an indigenous Nigerian plant belongs to the phylum Tracheophyta in the family Asteraceae. Investigation into the hot aqueous leaves extract revealed the presence of phytochemicals such as tannins, saponins, flavonoids and glycosides. Alkaloids were however absent. Examination of the roots also gave a brown oil which was identified by its spectra data such as infra-red, mass, proton and 13C nmr spectra as a furofuranoid lignan (5). Evidence of this comes from the presence of the diagnostic features of the furofurans which include the benzylic protons signal at δ4.50 as a doublet (J=7), the methylene protons at δ3.56 as double doublet (J=5; 10) and the methine protons at δ2.86 as multiplets. The structure of (5) was confirmed by synthesis using ethyl piperonoyl acetate (1). Comparison of the spectra of the naturally occurring compound (5) with that of the synthetic one confirmed that both compounds are the same.
Keywords
Furofuranoid Lignans, Phytochemicals, Aspilia africana, Tracheophyta, Asteraceae, Compositae
Reference
| [01] | Jack, I. R. and Okorosaye-Orubite, K. (2008). Phytochemical analysis and antimicrobial activity of the extract of leaves of fleabane Conyza sumatrensis. Journal of applied Science and Environmental Management 12(4), 63-65. |
| [02] | Nsi, E. W. and Dyegh A. H. (2004). Preliminary phytochemical screening and antimicrobial activity of Terminalia avicenniodes. International Journal of Science and Technology 2(3), 42-44. |
| [03] | Iwu, M. W., Duncan, A. R. and Okunji, C. O. (1999). New antimicrobials of plant origin. Janick Journal of Education, 457-462. |
| [04] | Anyadele, A and Adebiyi, A. O. (2007). Antimicrobial screening of extracts of Olax subscorpiodes. African Journal of Biotechnology 6(7) 868-870. |
| [05] | Okerelu, I. O. and Ani, C. I. (2001). The phytochemical analysis and antimicrobial screening of extracts of Tetracarpidium conophorum. Journal of Chemical Society of Nigeria 26, 1. |
| [06] | Alinor, L. J. (2006). Preliminary phytochemical and antimicrobial activity of Garcinia cola. Journal of Chemical Society of Nigeria 32 (2) 41-47. |
| [07] | Farnsworth, N. R. (1994). Biological and phytochemical screening of plants. Journal of Pharmaceutical Sciences 55, 225-236. |
| [08] | Ogbeche, A. K., Ajayi, G. O. and Onyeta, P (1997). Antimicrobial activities of the leaf extracts of Ageratum conyzoids. Nigerian Quarterly Journal of Hospital Medicine 7, 397-399. |
| [09] | Jack, I. R., Fekarurhobo, G. K. and BobManuel, R. B. (2003). Synthesis and isolation of 3,4-bis(3l,4l-methylenedioxyphenyl)butyrolactone from Crassostrea gasan. International Journal of Science and Technology 2, 23-25. |
| [10] | Ekaiko, M. U., Arinze, A. G., Iwe, C. U. and Asiegbu, E. I. (2016). Phytochemical constituents and antimicrobial potency of Aspilia africana, International Journal of Life Science Research, 4(1), 9-14. |
| [11] | Sherah, S. B., Onche, E. U., Mbonu, I. J., Olotu, P. N. and Lajide, L. (2014). Antimicrobial activity and chemical composition of the flowers of Aspilia africana. Advances in Life Science and Technology, 16, 54-57. |
| [12] | Okoli, C. O., Akah, P. A. and Okoli, A. S. (2007). Potentials of leaves of Aspilia africana (compositae) in wound care: an experimental evaluation, BMC Complementary and Alternative Medicine, 7(24), 1-7. |
| [13] | Dalziel, J. M. (1955). The useful plants of West Tropical Africa, Crown Agent for the Colonies, London, 217, 323-326,403. |
| [14] | Burkill, H. M. (1985). The Useful Plants of West Tropical Africa, 3, Royal Botanic Gardens, Kew (K), Vol 1, 267. |
| [15] | Odebiyi, E. O. and Ramstand, A. H. (1978). Investigation of phytochemical screening and antimicrobial activity of extracts of Tetracarpidium conophorum. Journal of Chemical society of Nigeria, 26,1. |
| [16] | Waterman, P. G. (1993). Methods in plants biochemistry. A Cad. Press. Vol. 8 |
| [17] | Pelter, A; Ward, R. S., Watson, D. J. and Jack, I. R. (1982). Synthesis and NMR spectra of 2,6- and 2,4-diaryl-3,7-dioxabicyclo[3,3,0]octanes. Journal of Chemical Society, Peckin 1, 183-190. |
| [18] | Williams, D. H. and Fleming, I. (1973). Spectroscopic methods in Organic chemistry (2nd ed. McGraw Hill Ltd UK) ch. 4, 56. |
| [19] | Anjaneyulu, A. S. R., Jagamoham, R. K., Kameswara, R. V., Ramachandra, R. L., Subramanyam, C., Pelter, A. and Ward, R. S. (1975). The structures of lignans from Gmelina arboreal Linn. Tetrahedron 31, 1277-1285. |
| [20] | Jack, I. R., Braide, S. A., Akani, G. C. and Okorosaye-Orubite, K. (2006). Isolation and Characterisation of ethylpiperonoyl acetate – a β-keto ester from the hermit crab Clibanarius africana. Niger Delta Biologia 5(2), 110-114. |
| [21] | Pelter, A. and Ward, R. S. (1978). Substituted furofurans. (Chemistry of lignans ed. C. B. S. Andra Univ. Press) ch. 7, 264. |
