ISSN: 2375-3765
American Journal of Chemistry and Application  
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Synthesis and Analgesic Activity Evaluation of Some New Benzimidazole Derivatives
American Journal of Chemistry and Application
Vol.4 , No. 5, Publication Date: Aug. 31, 2017, Page: 30-35
1130 Views Since August 31, 2017, 949 Downloads Since Aug. 31, 2017
 
 
Authors
 
[1]    

Asma Eswayah, Department of Medicinal and Pharmaceutical Chemistry, Faculty of Pharmacy, University of Tripoli, Tripoli, Libya.

[2]    

Souad Khaliel, Department of Chemistry, Faculty of Science, University of Benghazi, Benghazi, Libya.

[3]    

Shaban Saad, Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, University of Tripoli, Tripoli, Libya.

[4]    

Naima Shebani, Department of Medicinal and Pharmaceutical Chemistry, Faculty of Pharmacy, University of Tripoli, Tripoli, Libya.

[5]    

Omran Fhid, Department of Medicinal and Pharmaceutical Chemistry, Faculty of Pharmacy, University of Tripoli, Tripoli, Libya.

[6]    

Amal Belaid, Department of Medicinal and Pharmaceutical Chemistry, Faculty of Pharmacy, University of Tripoli, Tripoli, Libya.

[7]    

Tawssul Alsharif, Department of Medicinal and Pharmaceutical Chemistry, Faculty of Pharmacy, University of Tripoli, Tripoli, Libya.

[8]    

Haneen Elforjane, Department of Medicinal and Pharmaceutical Chemistry, Faculty of Pharmacy, University of Tripoli, Tripoli, Libya.

[9]    

Yousra Saadalla, Department of Chemistry, Faculty of Science, University of Benghazi, Benghazi, Libya.

[10]    

Ennam Baga, Department of Chemistry, Faculty of Science, University of Benghazi, Benghazi, Libya.

 
Abstract
 

A series of N-substituted benzimidazole derivatives (1-5) was synthesized. Benzimidazole nucleus was acylated in 1-position with benzoyl chloride in basic medium at room temperature to form N-acylated benzimidazole (1). Reaction of the N-acylated benzimidazole (1) with different amines yields the desired N-substituted benzimidazole derivatives (2-5). All the synthesized compounds (1-5) were evaluated in vivo for analgesic activity by acetic acid induced writhing and hot plate tests in mice. In comparison to the standard drug aspirin at the same dose (50mg/kg), compound 4 was the most potent as it decreased the number of writings to 17% comparing to control. However, aspirin resulted in a decrease equal to 12% of the control. In addition, all the test compounds except 5 produced some reduction in reaction time for hot plate test. Markedly, the effect was statistically significant with compounds 3 and 4.


Keywords
 

Benzimidazole, N-Acyl Benzimidazole, Analgesic Activity, Hot Plate Method, Acetic Acid Induced Writhing


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