ISSN: 2375-3811
International Journal of Biological Sciences and Applications  
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Class 1 Integrase and Genetic Cassettes blaoxa and blatem among Multi-Drug Resistant Shigella Isolates in Costa Rica
International Journal of Biological Sciences and Applications
Vol.1 , No. 1, Publication Date: Jul. 7, 2014, Page: 24-27
2538 Views Since July 7, 2014, 797 Downloads Since Apr. 14, 2015

Kenia Barrantes , Nutrition and Infection Section, Instituto de Investigaciones en Salud (INISA), University of Costa Rica, San José, Costa Rica.


Luz Chacón , Nutrition and Infection Section, Instituto de Investigaciones en Salud (INISA), University of Costa Rica, San José, Costa Rica.


Melissa Solano , Nutrition and Infection Section, Instituto de Investigaciones en Salud (INISA), University of Costa Rica, San José, Costa Rica.


Rosario Achí , Nutrition and Infection Section, Instituto de Investigaciones en Salud (INISA), University of Costa Rica, San José, Costa Rica.


Shigella is an important enteropathogen and the major cause of dysentery and diarrheal disease around the world. There are no studies related to the molecular detection of integrons among Shigella spp. isolates in Costa Rica. Here we are reporting for the first time the presence of class 1 integrase (intI-1) and extended spectrum β-lactamases genetic cassettes, blaOXA, and blaTEM among multidrug resistant Shigella isolates in Costa Rica. The antibiotic resistance pattern and presence of integrase class 1(intI-1) and genetic cassettes blaOXA and blaTEM were analyzed in 30 Shigella isolates (S. flexneri (83%) and S. sonnei (17%). Bacteria were collected at hospitals and cliniques in Costa Rica and exclusively from stools of individuals with diarrhea. from Costa Rica. Twenty nine out of 30 isolates were resistant to at least, one antibiotic. Multidrug resistance was observed in 26 out of 30 isolates (87%), and found to carry integrase class 1 (93%), and genetic cassettes blaOXA (76%) and blaTEM (7%)


Integron, Shigella, Costa Rica


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