






Vol.1 , No. 6, Publication Date: Jan. 21, 2016, Page: 93-99
[1] | Kalyani Bhole, Department of Instrumentation and Control, College of Engineering, Pune, India. |
[2] | Sudhir Agashe, Department of Instrumentation and Control, College of Engineering, Pune, India. |
Current situation in operation theatre is that anaesthesiologist is monitoring different physiological parameters, judging depth of anaesthesia and regulating drug rate manually. This manual drug dosing may go overdose or under-dose, as it depends upon experience and skill of anaesthesiologist. Under-dosing causes patient to feel pain. Overdosing may lead to unconsciousness leading to death. Automatic drug dosing will help anaesthesiologist to focus on more critical issues such as blood loss etc. In this focus, anaesthesia, when thought of as a multivariate, non-linear, and complex process fraught with uncertainties and handled by experts, can be mapped using fuzzy logic. A proportional integral derivative (PID) controller has proved useful in all types of industries. A novel approach is proposed involving a fuzzy inference system, which monitors the status of the patient, coupled with a PID controller, for closed-loop control of intravenous anaesthesia. By automating anaesthesia, ultimately total amount of drug infused is reduced and hence it results into fast recovery. One more advantage of automating it is that post anaesthesia side-effects will be reduced. A simulation with ten virtual patients showed that the proposed approach offered reliable control of the process and tracked input signals accurately despite the variations from patient to patient and disturbances to the system.
Keywords
Fuzzy Logic, Pharmacokinetics, Pharmacodynamics
Reference
[01] | Chang, Jing Jing, et al. "Automation of anaesthesia: a review on multivariable control." Journal of clinical monitoring and computing 29.2 (2015): 231-239. |
[02] | Beck, Carolyn. "Modelling and control of pharmacodynamics." European Journal of Control (2015). |
[03] | Sopasakis, Pantelis, Panagiotis Patrinos, and Haralambos Sarimveis. "Robust model predictive control for optimal continuous drug administration." Computer methods and programs in biomedicine 116.3 (2014): 193-204. |
[04] | Atchabahian, Arthur, and Thomas M. Hemmerling. "Robotic Anesthesia: How is it Going to Change Our Practice?" Anesthesiology and pain medicine 4.1 (2014). |
[05] | Van Heusden, Klaske, et al. "Design and clinical evaluation of robust PID control of propofol anaesthesia in children." Control Systems Technology, IEEE Transactions on 22.2 (2014): 491-501. |
[06] | K. Bhole, S. Agashe and Ashok Deshpande, “FPGA implementation of type 1 fuzzy inference system for intravenous anaesthesia”, Fuzzy systems (FUZZ), 2013 IEEE international Conference on, IEEE, 2013. |
[07] | Hemmerling, T. M., et al. "Evaluation of a novel closed-loop total intravenous anaesthesia drug delivery system: a randomized controlled trial." British journal of anaesthesia 110.6 (2013): 1031-1039. |
[08] | Hemmerling, Thomas M., Fabrizio Cirillo, and Shantale Cyr. Decision Support Systems in Medicine-Anaesthesia, Critical Care and Intensive Care Medicine. INTECH Open Access Publisher, 2012. |
[09] | Hemmerling, T. M., et al. "First robotic tracheal intubations in humans using the Kepler intubation system." British journal of anaesthesia 108.6 (2012): 1011-1016. |
[10] | Jin-Oh Hahn and et. al, “A Direct Dynamic Dose-Response Model of Propofol for Individualized Anaesthesia Care”, IEEE transactions on biomedical engineering, vol. 59, no. 2, February 2012, 571-578. |
[11] | J. Y. Lan and et. al, “Review: intelligent modelling and control in anaesthesia,” in Journal of Medical and Biological Engineering, vol. 32, pp. 293–308, 2012. |
[12] | K. A. Bhole, D. N. Sonawane, S. D. Agashe, Vinayak Desurkar and Ashok Deshpande, “FPGA implementation of Type 1 Fuzzy Inference System for Intravenous Anaesthetic drug delivery”, World conference on soft computing, 2011. |
[13] | Hemmerling, Thomas M. Decision support systems in anaesthesia, emergency medicine and intensive care medicine. INTECH Open Access Publisher, 2011. |
[14] | Hemmerling, Thomas M., et al. "Robotic Anesthesia–A Vision for the future of Anesthesia." Translational Medicine@ Uni Sa 1 (2011): 1. |
[15] | Mirza, Mansoor, Hamid Gholam Hosseini, and Michael J. Harrison. "A fuzzy logic-based system for anaesthesia monitoring." Engineering in Medicine and Biology Society (EMBC), 2010 Annual International Conference of the IEEE. IEEE, 2010. |
[16] | Caruso, Antonello LG, and Manfred Morari. "Model predictive control for propofol sedation." World Congress on Medical Physics and Biomedical Engineering, September 7-12, 2009, Munich, Germany. Springer Berlin Heidelberg, 2009. |
[17] | Caruso, Antonello LG, et al. "Control of drug administration during monitored anaesthesia care." Automation Science and Engineering, IEEE Transactions on6.2 (2009): 256-264. |
[18] | Hemmerling, Thomas, et al. "A novel closed-loop system to administer propofol comparison with manual control." Canadian Journal of Anesthesia55 (2008): 4738721-4738722. |
[19] | M. M. S. Anthony Absalom, An Overview of TCI and TIVA. Academia Press, 2008. |
[20] | Dunsmuir, Dustin, et al. "A knowledge authoring tool for clinical decision support." Journal of clinical monitoring and computing 22.3 (2008): 189-198. |
[21] | C. Vanlersberghe, and F. Camu, “Propofol”, in Modern Anaesthetics, Springer, 2008, Ch 11, pp. 227-252. |
[22] | R. D. Miller, Miller's Anaesthesia, 6th ed., e. Lee A Fleisher, Ed. Elsevier, 2005. |
[23] | Krol, Marina, and David L. Reich. "Development of a decision support system to assist anaesthesiologists in operating room." Journal of medical systems 24.3 (2000): 141-146. |
[24] | Schnider and et. al, “The influence of age propofol pharmacodynamics," Anaesthesiology, vol. 90, pp. 1502-1516, 1999. |
[25] | Zadeh, Lotfi A. "Fuzzy logic and approximate reasoning." Synthese 30.3-4 (1975): 407-428. |