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Vol.4 , No. 2, Publication Date: Mar. 2, 2018, Page: 34-45
 in South-West Nigeria, in experimental rats. Methods: Two hundred and fifty (250) adult female wistar rats were randomly selected and distributed into 10 groups of 25 rats each. Two mL/kg body weight of distilled water, a non-alcoholic non-polyherbal formulation (Fanta®), a polyherbal non-alcoholic formulation (YoyoBitters™) and an alcoholic non-polyherbal drink (Sabrina™) were orally administered to the control groups while BabyOku™, OsomoBitters™ and Ogidiga™ herbal formulations were administered to the experimental groups at doses of 2 mL/kg and 3 mL/kg body weights. Results: A dose- and tissue-dependent increase in induction of apoptotic DNA fragmentation was observed in the polyherbal groups relative to control groups. Also, an increase in micronucleated polychromatic erythrocytes was formed in a dose-dependent manner in the polyherbal groups when compared with the control groups. Conclusion: From our findings, polyherbal formulations may possess clastogenic, hematotoxic and genotoxic potentials in rats.&picture=http://www.aascit.org/aascit/decorators/img/journal/890.jpg)
| [1] | Ayokulehin Muse Kosoko, Department of Biochemistry, College of Biosciences (COLBIOS), Federal University of Agriculture, Abeokuta (FUNAAB), Nigeria. |
| [2] | Oluremi Joseph Olurinde, Department of Biochemistry, College of Biosciences (COLBIOS), Federal University of Agriculture, Abeokuta (FUNAAB), Nigeria. |
| [3] | Charles Ayobami Leigh, Department of Biochemistry, College of Biosciences (COLBIOS), Federal University of Agriculture, Abeokuta (FUNAAB), Nigeria. |
| [4] | Oluwatobi Temitope Somade, Department of Biochemistry, College of Biosciences (COLBIOS), Federal University of Agriculture, Abeokuta (FUNAAB), Nigeria. |
| [5] | Ridwan Olawale Akanbi, Department of Biochemistry, College of Biosciences (COLBIOS), Federal University of Agriculture, Abeokuta (FUNAAB), Nigeria. |
| [6] | Oluwatosin Adebisi Dosumu, Department of Biochemistry, College of Biosciences (COLBIOS), Federal University of Agriculture, Abeokuta (FUNAAB), Nigeria. |
| [7] | Solomon Rotimi, Department of Biological Sciences, Covenant University, Otta, Nigeria. |
Background: The current upsurge in the use of polyherbal remedies and coupled with loose regulation on public access to these products underscore research efforts to evaluate their biochemical effect, noting also that many of the polyherbal medicines lack scientific evidence to support their medicinal claims. Objective: We therefore investigated the potential genotoxicity, hematotoxicity and clastogenicity of three commonly consumed polyherbal formulations (OsomoBitters™, Ogidiga™ and BabyOku™) in South-West Nigeria, in experimental rats. Methods: Two hundred and fifty (250) adult female wistar rats were randomly selected and distributed into 10 groups of 25 rats each. Two mL/kg body weight of distilled water, a non-alcoholic non-polyherbal formulation (Fanta®), a polyherbal non-alcoholic formulation (YoyoBitters™) and an alcoholic non-polyherbal drink (Sabrina™) were orally administered to the control groups while BabyOku™, OsomoBitters™ and Ogidiga™ herbal formulations were administered to the experimental groups at doses of 2 mL/kg and 3 mL/kg body weights. Results: A dose- and tissue-dependent increase in induction of apoptotic DNA fragmentation was observed in the polyherbal groups relative to control groups. Also, an increase in micronucleated polychromatic erythrocytes was formed in a dose-dependent manner in the polyherbal groups when compared with the control groups. Conclusion: From our findings, polyherbal formulations may possess clastogenic, hematotoxic and genotoxic potentials in rats.
Keywords
Polyherbal Formulations, Genotoxicity, Hematotoxicity, Clastogenicity
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