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Vol.1 , No. 3, Publication Date: Jun. 11, 2015, Page: 56-69
| [1] | Azza A. Kamel, Chemical Industries Division, National Research Centre (NRC), Dokki, Cairo, Egypt. |
Phosphorus compounds in general and phosphonates in particular, are a corner stone in pharmaceutical drugs. Many of these compounds exhibit antifungal, antibacterial, anticancer and significant analgesic/antiinflammatory properties. Bisphosphonates and aminophosphonates, taken as representative examples, are important precursors of the corresponding bisphosphonic acid with, in many cases, remarkable pharmacologically interesting properties. The benefits of these compounds use in the prevention of bone mass loss in addition to their antitumor potential when used in the adjuvant setting were approved in many literatures. This article aims to shed light on phosphorus compounds as rising stars in pharmaceutical drugs in addition to their increasing role as antioxidants and antidiabetics. The available body of clinical trials supporting the use of these compounds in this setting was briefly scrutinized. These results recommended for a careful consideration of the role that phosphorus compounds can act as a new generation of antioxidants and antidiabetics. The emphasis is on the recent information added to this topic. Although the author has attempted the review to be encyclopedic with respect to the topics, the article is not exhaustive.
Keywords
Phosphorus Compounds, Bisphosphonates, Aminophosphonates, Antioxidants, Antidiabetics
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