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Vol.1 , No. 2, Publication Date: Apr. 21, 2015, Page: 25-37
 were synthesized and their antimicrobial activities were studied by using disc diffusion method. The compounds were screened for its antibacterial activity against gram positive bacteria such as Bacillus subtilis, Staphylococcus aureus, Staphylococcus epidermidis and gram negative bacteria such as E.coli, and Klebsiella pneumoniae. It was observed that 2-chloro-4’-methoxy-3’-nitro benzil and 2,2’-dichloro benzil showed anti bacterial activity in a dose dependent manner. The compound with chloro substituent showed potent antibacterial activity against Staphylococcus aureus bacterial strain in comparison with bromo substituted and unsubstituted benzil. The susceptibility of the microorganisms to the synthesized benzils was compared with each other and with the standard antibiotic streptomycin. The antimicrobial activity of the compound reveals that they act as a source of potent antimicrobial agents.&picture=http://www.aascit.org/aascit/decorators/img/journal/890.jpg)
| [1] | Nithya G., Department of Chemistry, School of Engineering, Vels University, Pallavaram, Chennai, Tamil Nadu, India. |
| [2] | Charles C. Kanakam, Depatment of Chemistry, Formerly Presidency College, University of Madras, Tamil Nadu, India. |
| [3] | Sudha R., Department of Chemistry, School of Engineering, Vels University, Pallavaram, Chennai, Tamil Nadu, India. |
| [4] | Vanitha V., Department of Biochemistry, School of Life sciences, Vels University, pallavaram, Chennai, Tamilnadu, India. |
Benzils are well known for their bacterial activity, their coordination compounds containing diketone are reported to possess antimicrobial activity. A series of different substituted benzils (benzil, 4,4’-dibromo benzil, 2,2-dichloro benzil, 2’-chloro-4-methoxy-3-nitro benzil) were synthesized and their antimicrobial activities were studied by using disc diffusion method. The compounds were screened for its antibacterial activity against gram positive bacteria such as Bacillus subtilis, Staphylococcus aureus, Staphylococcus epidermidis and gram negative bacteria such as E.coli, and Klebsiella pneumoniae. It was observed that 2-chloro-4’-methoxy-3’-nitro benzil and 2,2’-dichloro benzil showed anti bacterial activity in a dose dependent manner. The compound with chloro substituent showed potent antibacterial activity against Staphylococcus aureus bacterial strain in comparison with bromo substituted and unsubstituted benzil. The susceptibility of the microorganisms to the synthesized benzils was compared with each other and with the standard antibiotic streptomycin. The antimicrobial activity of the compound reveals that they act as a source of potent antimicrobial agents.
Keywords
Antimicrobial Activity, Synthesis, Gram Positive Bacteria, Gram Negative Bacteria
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