Individual Information
 
 

Rustam Ali
Research Scientist
HHMI and UT Southwestern Medical Center

Educational Qualification
From 2008 to 2014, PhD , India
From 2006 to 2008, M.Sc (Biotechnology) , India
Research Interests
Biochemistry/Structural Biology
Biophysics
Biomolecular NMR
Spectroscopy
Cell Biology
Molecular Biology
Microbiology
Protein Chemistry
Structural Cell Biology
Protein folding & aggregation
Enzyme technology
Chemical Biology
Work Experience
From 01/2018 to Present, Postdoctoral researcher , Howard Hughes medical Institute and Biophysics Department, UT Southwestern Medical center, USA
From 01/2016 to 12/2017, AHA Postdoctoral Fellow , American Heart Association.Howard Hughes medical Institute and Biophysics Department, UT Southwestern Medical center, USA
From 09/2014 to 12/2015, HHMI Postdoctoral Research Associate , Howard Hughes medical Institute and Biophysics Department, UT Southwestern Medical center, USA
From 12/2013 to 09/2014, Research Associate , Molecular Biophysics Unit, Indian Institute of Science, Bangalore
From 08/2013 to 12/2013, Senior Research Fellow , Molecular Biophysics Unit, Indian Institute of Science, Bangalore
From 05/2007 to 07/2007, Summer Research Fellow , Center for Cellular and Molecular Biology, India
Projects
From 09/2014 to Present, Study of monomeric actin dynamics and its effect on actin filament assembly and cardiovascular diseases

From 09/2014 to Present, Understanding molecular basis of LLPS and its role in bimolecular condensate formation and neurodegenerative diseases

From 08/2008 to 09/2014, Deciphering Structure-Function Relationship in a two-subunit-type GMP Synthetase by Solution NMR spectroscopy.

From 2007 to 2008, Production of xylanase from alkalano-thermophilic bacteria RA-08

From 06/2007 to 07/2007, Cloning, expression, 15N isotope labeling and purification of D-aminoacyl tRNA deacylase from E. coli

Selected Publications
Journal Articles
1. Nuclear import receptor inhibits phase separation of FUS through binding to multiple sites, Cell. 2018, 173, 693-705. Yoshizawa*, Ali R*, Jiou J, Fung HC, Burke KA, Kim SJ, Lin Y, Peeples WB, Saltzberg D, Soniat, Baumhardt JM, Oldenbourg R, Sali A, Fawzi NL, Rosen MK and Chook YM. *Equal contribution
2. Sequence Determinants of Intracellular Phase Separation by Complex Coacervation of a Disordered Protein. Mol Cell. 2016, 63, 72-85. Pak CW, Kosno M, Holehouse AS, Padrick SB, Mittal A, Ali R, Yunus AA, Liu DR, Pappu RV, Rosen MK.
3. Methyl labeling and TROSY MR spectroscopy of proteins expressed in the eukaryote Pichia pastoris. J Bimol NMR. 2015 May 30. PMID: 26025061. Clark L, Zahm JA, Ali R, Kukula M, Bian L, Gardner KH, Rosen MK, Rosenbaum DM.
4. Solution MR Structure of the GATase Subunit and Structural Basis of the Interaction between GATase and ATPPase Subunits in a two-subunit-type GMPS from Methanocaldococcus jannaschii. Biochemistry. 2013, 52, 4308?4323. Ali R, Kumar S, Balaram H, Sarma SP.
5. 1H, 13C, 15N assignment and secondary structure determination of glutamine amido transferase subunit of gaunosine monophosphate synthetase from Methanocaldococcus jannaschii. Biomol NMR Assign. 2012, 6, 193- 196.Ali R, Kumar S, Balaram H, Sarma SP.
6. Production of Alkaline Xylanase by Alkalo-thermophilic Bacteria, Bacillus halodurans, MTCC 9512 isolated from Dung. Current Trends in Biotechnology and Pharmacy, 2009, 3, 90-96.Garg S, Ali R, Kumar A.