Individual Information
Rustam Ali
Research Scientist
HHMI and UT Southwestern Medical Center
Educational Qualification
From 2008 to 2014, PhD , India
From 2006 to 2008, M.Sc (Biotechnology) , India
Research Interests
Biochemistry/Structural Biology
Biophysics
Biomolecular NMR
Spectroscopy
Cell Biology
Molecular Biology
Microbiology
Protein Chemistry
Structural Cell Biology
Protein folding & aggregation
Enzyme technology
Chemical Biology
Work Experience
From 01/2018 to Present, Postdoctoral researcher , Howard Hughes medical Institute and Biophysics Department, UT Southwestern Medical center, USA
From 01/2016 to 12/2017, AHA Postdoctoral Fellow , American Heart Association.Howard Hughes medical Institute and Biophysics Department, UT Southwestern Medical center, USA
From 09/2014 to 12/2015, HHMI Postdoctoral Research Associate , Howard Hughes medical Institute and Biophysics Department, UT Southwestern Medical center, USA
From 12/2013 to 09/2014, Research Associate , Molecular Biophysics Unit, Indian Institute of Science, Bangalore
From 08/2013 to 12/2013, Senior Research Fellow , Molecular Biophysics Unit, Indian Institute of Science, Bangalore
From 05/2007 to 07/2007, Summer Research Fellow , Center for Cellular and Molecular Biology, India
Projects
From 09/2014 to Present, Study of monomeric actin dynamics and its effect on actin filament assembly and cardiovascular diseases
From 09/2014 to Present, Understanding molecular basis of LLPS and its role in bimolecular condensate formation and neurodegenerative diseases
From 08/2008 to 09/2014, Deciphering Structure-Function Relationship in a two-subunit-type GMP Synthetase by Solution NMR spectroscopy.
From 2007 to 2008, Production of xylanase from alkalano-thermophilic bacteria RA-08
From 06/2007 to 07/2007, Cloning, expression, 15N isotope labeling and purification of D-aminoacyl tRNA deacylase from E. coli
Selected Publications
From 2008 to 2014, PhD , India
From 2006 to 2008, M.Sc (Biotechnology) , India
Research Interests
Biochemistry/Structural Biology
Biophysics
Biomolecular NMR
Spectroscopy
Cell Biology
Molecular Biology
Microbiology
Protein Chemistry
Structural Cell Biology
Protein folding & aggregation
Enzyme technology
Chemical Biology
Work Experience
From 01/2018 to Present, Postdoctoral researcher , Howard Hughes medical Institute and Biophysics Department, UT Southwestern Medical center, USA
From 01/2016 to 12/2017, AHA Postdoctoral Fellow , American Heart Association.Howard Hughes medical Institute and Biophysics Department, UT Southwestern Medical center, USA
From 09/2014 to 12/2015, HHMI Postdoctoral Research Associate , Howard Hughes medical Institute and Biophysics Department, UT Southwestern Medical center, USA
From 12/2013 to 09/2014, Research Associate , Molecular Biophysics Unit, Indian Institute of Science, Bangalore
From 08/2013 to 12/2013, Senior Research Fellow , Molecular Biophysics Unit, Indian Institute of Science, Bangalore
From 05/2007 to 07/2007, Summer Research Fellow , Center for Cellular and Molecular Biology, India
Projects
From 09/2014 to Present, Study of monomeric actin dynamics and its effect on actin filament assembly and cardiovascular diseases
From 09/2014 to Present, Understanding molecular basis of LLPS and its role in bimolecular condensate formation and neurodegenerative diseases
From 08/2008 to 09/2014, Deciphering Structure-Function Relationship in a two-subunit-type GMP Synthetase by Solution NMR spectroscopy.
From 2007 to 2008, Production of xylanase from alkalano-thermophilic bacteria RA-08
From 06/2007 to 07/2007, Cloning, expression, 15N isotope labeling and purification of D-aminoacyl tRNA deacylase from E. coli
Selected Publications
Journal Articles
1. |
Nuclear import receptor inhibits phase separation of FUS through binding to multiple sites, Cell. 2018, 173, 693-705. Yoshizawa*, Ali R*, Jiou J, Fung HC, Burke KA, Kim SJ, Lin Y, Peeples WB, Saltzberg D, Soniat, Baumhardt JM, Oldenbourg R, Sali A, Fawzi NL, Rosen MK and Chook YM. *Equal contribution |
2. |
Sequence Determinants of Intracellular Phase Separation by Complex Coacervation of a Disordered Protein. Mol Cell. 2016, 63, 72-85. Pak CW, Kosno M, Holehouse AS, Padrick SB, Mittal A, Ali R, Yunus AA, Liu DR, Pappu RV, Rosen MK. |
3. |
Methyl labeling and TROSY MR spectroscopy of proteins expressed in the eukaryote Pichia pastoris. J Bimol NMR. 2015 May 30. PMID: 26025061. Clark L, Zahm JA, Ali R, Kukula M, Bian L, Gardner KH, Rosen MK, Rosenbaum DM. |
4. |
Solution MR Structure of the GATase Subunit and Structural Basis of the Interaction between GATase and ATPPase Subunits in a two-subunit-type GMPS from Methanocaldococcus jannaschii. Biochemistry. 2013, 52, 4308?4323. Ali R, Kumar S, Balaram H, Sarma SP. |
5. |
1H, 13C, 15N assignment and secondary structure determination of glutamine amido transferase subunit of gaunosine monophosphate synthetase from Methanocaldococcus jannaschii. Biomol NMR Assign. 2012, 6, 193- 196.Ali R, Kumar S, Balaram H, Sarma SP. |
6. |
Production of Alkaline Xylanase by Alkalo-thermophilic Bacteria, Bacillus halodurans, MTCC 9512 isolated from Dung. Current Trends in Biotechnology and Pharmacy, 2009, 3, 90-96.Garg S, Ali R, Kumar A. |