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Vol.4 , No. 2, Publication Date: Mar. 23, 2018, Page: 35-39
 fruit against penconazole-induced changes in blood hematological and mineral profiles in rats. Rats were treated either with penconazole (67 mg/kg body weight), <i>N. retusa</i> fruit aqueous extract (300 mg/kg body weight) or with penconazole associated with <i>N. retusa</i>. Penconazole was administered intraperitoneally every 2 days from day 7 until day 15, the sacrifice day, while <i>N. retusa</i> extract was administered daily by gavage during 15 days. Compared to the controls, the penconazole-treated group showed significant differences in several hematological parameters, including a decrease in red blood cells’ count, hemoglobin concentration and hematocrit value, and an increase in white blood cells and platelets’ counts. Moreover, iron, calcium and magnesium plasma levels decreased. <i>N. retusa</i> administration to penconazole-exposed rats improved the blood hematological and mineral profiles. Our data indicated that <i>N. retusa</i> fruit might be favorable to avoid changes in blood hematological and mineral parameters associated with penconazole exposure.&picture=http://www.aascit.org/aascit/decorators/img/journal/980.jpg)
| [1] | Mariem Chaâbane, Animal Physiology Laboratory, Department of Life Sciences, Sciences Faculty of Sfax, University of Sfax, Sfax, Tunisia; Enzymes and Bioconversion Unit, Department of Biological Engineering, National Engineering School of Sfax, University of Sfax, Sfax, Tunisia. |
| [2] | Imen Ghorbel, Animal Physiology Laboratory, Department of Life Sciences, Sciences Faculty of Sfax, University of Sfax, Sfax, Tunisia. |
| [3] | Awatef Elwej, Animal Physiology Laboratory, Department of Life Sciences, Sciences Faculty of Sfax, University of Sfax, Sfax, Tunisia. |
| [4] | Choumous Kallel, Hematolology Laboratory, CHU Habib Bourguiba, University of Sfax, Sfax, Tunisia. |
| [5] | Kamel Jamoussi, Biochemistry Laboratory, Department of Biochemistry, CHU Hedi Chaker, University of Sfax, Sfax, Tunisia. |
| [6] | Semia Ellouze Chaabouni, Enzymes and Bioconversion Unit, Department of Biological Engineering, National Engineering School of Sfax, University of Sfax, Sfax, Tunisia. |
| [7] | Najiba Zeghal, Animal Physiology Laboratory, Department of Life Sciences, Sciences Faculty of Sfax, University of Sfax, Sfax, Tunisia. |
| [8] | Nejla Soudani, Animal Physiology Laboratory, Department of Life Sciences, Sciences Faculty of Sfax, University of Sfax, Sfax, Tunisia. |
Our study investigated the protective effect of Nitraria retusa (N. retusa) fruit against penconazole-induced changes in blood hematological and mineral profiles in rats. Rats were treated either with penconazole (67 mg/kg body weight), N. retusa fruit aqueous extract (300 mg/kg body weight) or with penconazole associated with N. retusa. Penconazole was administered intraperitoneally every 2 days from day 7 until day 15, the sacrifice day, while N. retusa extract was administered daily by gavage during 15 days. Compared to the controls, the penconazole-treated group showed significant differences in several hematological parameters, including a decrease in red blood cells’ count, hemoglobin concentration and hematocrit value, and an increase in white blood cells and platelets’ counts. Moreover, iron, calcium and magnesium plasma levels decreased. N. retusa administration to penconazole-exposed rats improved the blood hematological and mineral profiles. Our data indicated that N. retusa fruit might be favorable to avoid changes in blood hematological and mineral parameters associated with penconazole exposure.
Keywords
Penconazole, Rats, Hematological and Mineral Profiles, Nitraria retusa
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